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Pharmacodynamic and Pharmacokinetic Profiles of Sacubitril/Valsartan (LCZ696) in Patients with Heart Failure and Reduced Ejection Fraction
Authors:Zhanna Kobalava  Yulia Kotovskaya  Oleg Averkov  Elena Pavlikova  Valentine Moiseev  Diego Albrecht  Priya Chandra  Surya Ayalasomayajula  Margaret F. Prescott  Parasar Pal  Thomas H. Langenickel  Pierre Jordaan  Iris Rajman
Affiliation:1. Center of Applied Clinical Pharmacology, Peoples Friendship University of Russia, Moscow, Russia;2. Translational Medicine, Novartis Pharma AG, Basel, Switzerland;3. Drug Metabolism and Pharmacokinetics, Clinical Pharmacokinetic/Pharmacodynamics, Novartis Institute for Biomedical Research, East Hanover, NJ, USA;4. Clinical Development and Medical Affairs, Novartis Pharmaceutical Corporation, East Hanover, NJ, USA;5. Biostatistical Sciences, Novartis Healthcare Private Limited, Hyderabad, India
Abstract:
Keywords:Heart failure  LCZ696  Pharmacodynamics  Pharmacokinetics  Sacubitril/valsartan
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