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Antigenic homology between a marsupial homocytotropic antibody and human IgE
Authors:N R Lynch  K J Turner
Affiliation:1. Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA;2. Institut für Funktionelle Genomforschung der Mikroorganismen, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany;1. Doctoral Academic Study, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia;2. Department for Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia;3. Public Health Institute Kragujevac, Nikole Pasica 1, 34000 Kragujevac, Serbia;4. Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia;5. Department of Gynecology and Obstetrics, Clinical Center Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia;1. Centre for Animal Health Innovation, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Locked Bag 4, Maroochydore DC, QLD 4558, Australia;2. Medical Engineering Research Facility, Institute of Health & Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, 4059 Brisbane, Queensland, Australia;3. Vaccine and Infectious Disease Organization – International Vaccine Centre, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada;1. Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA;2. College of Veterinary Medicine, China Agricultural University, Beijing, China;3. Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA
Abstract:The ability of anti-human IgE antiserum to elicit reverse cutaneous anaphylactic (RCA) reactions in the skin of the marsupial Setonix brachyurus (the quokka) suggested that the quokka homocytotropic antibody (HCA) might share antigenic determinants with human IgE. The application of the ‘Phadebas’ (Pharmacia) assay for human IgE to quokka sera provided further evidence for the existence of antigenic cross-reactivity between these antibodies.
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