1502例孕中期孕妇产前三联筛查结果分析

目的探讨应用母亲血清标志物检查筛查胎儿唐氏综合征的临床价值。方法应用ACCESS全自动免疫化学发光仪及配套试剂对妊娠15—22周的1502例孕妇进行血清AFP、β-hCG、μE3的测定，风险率〉1：380定为筛查阳性，再作羊水检查进行产前诊断。结果1502例孕妇中筛查为阳性者47例（3．13％），接受产前诊断者45例，有3例21-三体核型胎儿，2例神经管畸形胎儿，1例18-三体综合征胎儿。结论孕中期应用母亲血清生化指标筛查唐氏综合征胎儿并结合产前诊断是减少唐氏综合征患儿出生的有效方法。

Analysis of triple test in prenatal screen for 1502 second trimester pregnant women

Objective To study the clinical value of maternal serum marker screening for fetal Down＇ s syndrome. Methods Serum AFP,β-hCG,μE3 in 1 502 pregnant women ranged from 15th to 22nd gestational week were detected by automatic immunochemiluminescence apparatus and its corollary reagent, and the test results were regarded as positive when risk probability was over 1： 380. The anmiocentesis was done for prenatal diagnosis. Results Forty-seven of 1 502 pregnant women were positive （3. 13% ）. The prenatal diagnosis was performed in 45 pregnant women, of whom three were 21-Trisomy syndrome, two were neural tube defects and one was 18-Trisomy Syndrome. Conclusion It is an effective method to reduce infants with Down＇ s syndrome by detecting second trimester maternal serum biochemical markers and combining prenatal diagnosis.