血脂康对冠心病粘附分子表达的影响

目的探讨动脉粥样硬化（AS）时血脂异常对单核细胞（MC）粘附分子表达及调脂干预对其产生的影响。方法选择冠心病不稳定性心绞痛（UA）患者30例，并经血脂康调脂治疗3个月后随访，同时选取正常对照者30例，检测研究对象的TC、LDL—C、MC表面CD11a、CD11b和CD18阳性细胞百分率，观察其变化以及测定冠心病患者血脂康调脂治疗前后血清P-选择素、ICAM-1、Ox-LDL的水平，分析之间的相关性。结果不稳定性心绞痛患者血清Ox-LDL水平明显增高，与血清P-选择素水平呈显著正相关关系；LDL与CD11a、CD18相关显著。经血脂康调脂治疗后，患者在血清TC、LDL—C水平下降的同时，血清P-选择素、ICAM-1、Ox—LDL水平也显著降低，提示通过血脂康调脂干预治疗，能够阻止不稳定性心绞痛患者冠状动脉粥样病变的炎症反应，改善血管内皮细胞功能，延缓冠状动脉粥样病变的进展。结论血脂康抑制Ox-LDI．诱导的粘附分子表达是其独立于调脂之外的另一抗AS作用。

Effect of xuezhikang on adhesion molecules expression in patients with coronary heart disease

Objective To investigate the effect of lipid abnormality and lipid -medulating therapy on monocyte adhesion molecules expression in patients with atheroselerosis. Methods Thirty patients with unstable angina （UA） and 30 normal controls were enrolled in this study. After 3 months of treatment,the percentage of CDlla, CDllb and CD18 positive monocytes were measured. The levels of serum P-seleetin, ICAM-1 and Ox-LDL in these patients before and after treatment with XZK were determined. Then relavent correlations were further studied. Results Serum Ox-LDL levels significantly increased in patients with UA and positively correlated with serum P-selectin. Meanwhile there were also positive relationships between LDL and CD11 a, CD18. Furthermore, after lipid-modulating therapy, with decrease of serum TC and LDL-e,the serum P-selectin, ICAM-1 and Ox-LDL levels were also decreased significantly, which suggested XZK could prevent inflammatory reaction of atherosclerosis, improve the function of vascular endothelial cells and delay the process of coronary artery atherosclerosis. Conclusion XZK could decrease Ox-LDL induced adhesion molecules expression, which may be its another anti-atherosclerosis mechanism independent of lipid- modulating role.