辛伐他汀对高血压病患者血压与C反应蛋白的影响

目的研究他汀类药物的降脂外效应，对血压及C反应蛋白的影响。方法随机选择2007-02—20094）2因高血压病住院的患者68例，其中男性46例，女性22例，年龄（66．2±7．6）岁，随机分为两组：治疗组34例，给予培哚普利＋苯磺酸氨氯地平联合降压的基础上加用辛伐他汀；对照组34例，使用培哚普利＋苯磺酸氨氯地平，治疗4周，观察两组血脂、血压及C反应蛋白变化情况。结果（1）治疗组总胆固醇、甘油三脂及低密度脂蛋白、胆固醇明显低于对照组；（2）治疗组血压降低幅度明显低于对照组；（3）治疗组C反应蛋白明显低于对照组。结论辛伐他汀可以降低高血压病患者的血压，同时降低其血清C反应蛋白的水平。

Effect of simvastatin on blood pressure and C-reactive protein in patients with essential hypertension

Objective To research the effeet of simvastatin on lipid-lowing, blood pressure and C-reactive protein. Methods Sixty-eight patients with essential hypertension in Liuzhou Tumor Hospital from February 2007 to February 2009 were randomly selected, including 46 males and 22 females with an average age of （ 66. 2 ± 7.6 ）. The study group with 34 patients was given simvastatin on a basis of perindopril and amlodipine besylate, the control group was given perindopril and amlodipine besylate, the change of lipid, blood pressure and C-reactive protein were ob- served after 4 weeks. Results The total cholesterol, triglycerides, low density lipoprotein and cholesterol of the patients in treatment group were much lower than that in control group, the decreased degree of blood pressure and C-reactive protein of the patients in treatment group were much lower than that in control group. Conclusion Simvastatin could reduce the blood pressure and serum C-reactive protein of the patients with essential hypertension.