CD44v6及Ezrin在结肠癌中的表达及临床意义

目的探讨CD44v6、Ezrin蛋白在结肠癌组织中的表达及临床意义。方法应用免疫组化S—P法，检测47例结肠癌、20例正常结肠组织中CD44v6、Ezrin蛋白的表达。结果CD44v6及Ezrin蛋白在结肠癌组织中的阳性率分别为68．09％（32／47）、74．47％（35／47），CD44v6及Ezrin蛋白在正常结肠组织阳性表达率为25．00％（5／20）、100．00％（20／20），有淋巴转移患者的Ezrin蛋白、CD44v6阳性率高于无淋巴转移患者（P〈0．05）；Ezrin蛋白在结肠癌组织中主要表达于胞浆，在正常肠组织主要表达于胞膜。结论Ezrin蛋白、CD44v6的表达有助于综合判断结肠癌的恶性程度和转移潜能。Ezrin蛋白有望成为判断预后的新指标。

Expression of CD44v6 and Ezrin in colon cancer and its clincal significance

Objective To investigate the clincal significance of the expression of CD44v6 and Ezrin protein in colon cancer. Methods Immunohistochemical method was used to examine CD44v6 and Ezrin protein of the sections from 47 cases of colon cancer and 20 normal colon tissues. Results The positive rate of CD44v6 and Ezrin expression was 68.09% （32/47） ,74. 47% （ 35/47 ） in colon cancer and was 25.00% （ 5/20）,100. 00% （20/20） in normal tissue. The CD44v6 and Ezrin positive rate of colon cancer with lymph nodes metastasis was significantly higher than that of colon cancer without （ P 〈 0. 05 ）. Besides, expression area of Ezrin was often in the cytoplasma for colon cancer and in the cell membrane for normal colon tissues. Conclusion The results suggest that detecting the expression of protein Ezrin and CD4v6 is helpful to judge malignancy degree and metastasis potentiality of colon carcinoma. The protein Ezrin is hoped to be a new index to judge prognosis.