血清心肌酶谱及心肌肌钙蛋白1检测在手足口病患儿心肌损伤中的临床实验研究

目的探讨手足口病患儿血清心肌酶谱及心肌肌钙蛋白1（cTn1）对心肌功能损伤的临床意义。方法收集南宁地区2008-04—2009-05手足口病（HFMD）患儿83例，用日本生产的Automatic Analyzer HITACHI7600-120型检测仪检测心肌酶谱（AST、LDH、CK及CK—MB）和美国亚培生产的AbbottAxSYM系统全自动化学发光免疫分析系统检测cTn1。结果83例HFMD患儿的血清心肌酶谱AST、LDH、CK、CK．MB及cTn1检测结果均明显高于正常对照组（P〈O．05或P〈0．01）。结论联合检测HFMD患儿血清心肌酶谱（特别是CK-MB）及cTn1在早期诊断HFMD及了解该病的损伤情况有着重要的临床意义。

Study on the clinical experiment on the detection of serum myocardial enzymogram and cTnl in myocardial injury of hand foot mouth disease children

Objective To study the clinical significance of serum myocardial enzymogram and troponin 1 for juding the myocardial injury of hand foot mouth disease （HFMD） children. Methods The myocardial enzymogram （AST, LDH, CK and CK-MB） in serum of 83 HFMD children collected in Nanning area from April 2008 to June 2009 were detected by Automatic Analyzer HITACHI 7600 120, and the cardiac troponin 1 （cTnl） in serum of 83 FHMD children were detected by Abbott AxSYM chemilumin-escent immunoassay. Results Compared with healthy volunteers AST, LDH, CK, CK-MB and cTnl in serum of 83 HFMD children increased significantly（ P 〈 0. 05 or P 〈 0. 01）. Conclusion Combined detection of serum cTnl and myocardial enzymogram especially （CK-MB） have the important clinical meaning for the early diagnosing HFMD and judging myocardial injury.