Epididymal ultrastructural changes associated with chronic cholestasis after bile duct ligation in adult rats

Testicular atrophy and testesterone insufficiency have been commonly reported associated with chronic liver diseases. Though testosterone dependent, the epididymal changes induced by liver disease have never been studied before. Thus, this study aimed to assess the ultrastructural events in the epididymis of rats with chronic obstructive jaundice. Chronic cholestasis induced many epididymal structural alterations manifested by the reduced tubular diameters, thickening of the tubular basement membrane, and regression of the principal cells. This was accompanied with reduction of principal cell organelles, cytoplasmic vacuolations, nuclear alterations, and stereovilli loss. The results establish that chronic cholestasis causes epididymal structural changes due to androgen deficiency.