Clinical characteristics and prognostic factors of sinonasal undifferentiated carcinoma: a multicenter study |
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| Authors: | Guillaume de Bonnecaze MD MSc Benjamin Verillaud MD PhD Leonor Chaltiel PhD Sylvestre Fierens MD Mark Chapelier MD Cécile Rumeau MD MSc Olivier Malard MD PhD Marie Gavid MD MSC Xavier Dufour MD PhD Christian Righini MD PhD Emmanuelle Uro‐coste MD PhD Michel Rives MD Christine Bach MD Bertrand Baujat MD PhD François Janot MD PhD Ludovic de Gabory MD PhD Sebastien Vergez MD PhD |
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| Affiliation: | 1. Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital Rangueil‐Larrey, Toulouse, France;2. Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital Lariboisière, Paris, France;3. Biostatistics Department, L'Institut Universitaire du Cancer de Toulouse‐Oncopole (IUCT‐Oncopole), Cancer Institute, Toulouse, France;4. Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital Pellegrin, Bordeaux, France;5. Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital of Nancy, Nancy, France;6. Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital Nantes, Nantes, France;7. Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital Saint‐Etienne, Saint‐Priest‐en‐Jarez, France;8. Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital Poitiers, Poitiers, France;9. Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital Grenoble, Grenoble, France;10. Department of Pathology, IUCT‐Oncop?le, Cancer Institute, Toulouse, France;11. Radiation Oncology Department, IUCT‐Oncop?le, Cancer Institute, Toulouse, France;12. Department of Otorhinolaryngology–Head and Neck Surgery, Hopital Foch, Suresnes, France;13. Department of Otorhinolaryngology–Head and Neck Surgery, Tenon Hospital, Paris‐Est University, Paris, France;14. Department of Otorhinolaryngology–Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France |
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| Abstract: | Background Sinonasal undifferentiated carcinoma (SNUC) is a very rare entity with a poor prognosis. Due to the lack of studies on the subject, evidence is lacking concerning its management. Methods A multicenter collaborative study was conducted to assess treatment strategy, oncological outcome, and prognostic factors. Results Definitive analyses focused on 54 patients with a majority of advanced stage; the 3‐year overall survival (OS) and 3‐year recurrence‐free survival (RFS) rates were, respectively, 62.4% and 47.8%. During the follow‐up, 18 patients (33.3%) died, 10 (18.5%) developed metastases, 7 had lymph‐node involvement (13%), and 12 (22.2%) showed recurrence or local progression. In univariate analyses, treatment modalities associated with improved RFS were induction chemotherapy (p = 0.02) and intensity‐modulated radiotherapy (p = 0.007). In the multivariate analyses, only induction chemotherapy (p = 0.047, hazard ratio [HR] = 0.39) was significantly associated with improved RFS. Conclusion Multimodal therapies including induction chemotherapy and intensity‐modulated radiotherapy may improve the prognosis of SNUC; surgery might improve local control. Further multicenter studies are required. |
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| Keywords: | sinus cancer sinonasal undifferentiated carcinoma multicenter study induction chemotherapy multimodal approach |
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