Free d-serine concentration in normal and Alzheimer human brain |
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| Authors: | Yoko Nagata Mauro Borghi George H. Fisher Antimo D'Aniello |
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| Affiliation: | aDepartment of Life Science, Himeji Institute of Technology, Shosha, Himeji 671-22, Japan;bDepartment of Medical Jurisprudence, Policlinico Le Scotte, University of Siena, Italy;cDepartment of Chemistry, Barry University, Miami Shores, FL 33161, USA;dDepartment of Biochemistry, Stazione Zoologica “A. Dohrn” Villa Communale, Naples, Italy |
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| Abstract: | We have analyzed both free l- and d-serine in frontal cortex of normal and Alzheimer human brain by high-performance liquid chromatography (HPLC). There was no significant difference between the two brains. In normal brain, l- and d-serine concentrations were 666 ± 222 and 66 ± 41 nmol/g of wet tissue, respectively, and the ratio of d-isomer to l-isomer ( ) was 0.099 ± 0.031. In Alzheimer brain, the concentrations were 750 ± 150 and 66 ± 40 nmol/g, respectively, and the  ratio was 0.086 ± 0.040. Thus, it was shown that the free d-serine concentration in the Alzheimer brain was comparable to that in the normal brain. |
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| Keywords: | font-variant: small-caps" >d-Serine Alzheimer disease Human brain Frontal cortex |
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