麦冬多糖平喘和抗过敏作用研究

目的 :观察麦冬多糖的平喘和抗过敏作用。方法 :通过整体实验 ,观察麦冬多糖 (POT)对氨雾引起小鼠咳嗽和对以组胺和乙酰胆碱混合液引起豚鼠支气管收缩及对小鼠耳异种被动皮肤过敏 (PCA)和以卵白蛋白诱发的致敏豚鼠支气管收缩的影响。结果 :POT 2 0 0mg/kg对氨雾引起的小鼠咳嗽无明显的影响 ;对乙酰胆碱和组胺混合液引起的豚鼠支气管收缩有极显著的抑制作用 (P <0 .0 0 1 ) ;对小鼠PCA反应的抑制率为 3 2 .79% ;可显著延长卵白蛋白所致的致敏豚鼠呼吸困难、抽搐和跌倒的潜伏期 (P <0 .0 0 1 )。结论 :麦冬多糖能拮抗乙酰胆碱和组胺混合液刺激引起的正常豚鼠和卵白蛋白引起的致敏豚鼠的支气管平滑肌收缩 ,抑制致敏豚鼠哮喘的发生并具有较显著的抗小鼠耳异种被动皮肤过敏的作用

A study on the antianaphylactin and antiasthmatic activity of polysaccharide from ophiopgonis tuber

OBJECTIVE:To observe the antianaphylactin and antiasthmatic activity of polysaccharide from ophiopgonis tuber(POT).METHODS:In rivo observing the inhibitive effects of POT on the cough caused by ammoniacal smoke in mice and the bronchospasm caused by the mixture of histamine and acetylcholine or egg albumin in normal gainea pigs and the passive cutaneous anaphylaxis(PCA) reaction in mice,respectively.RESULTS:POT at doses of 200 mg/kg had significant antagonistic effect on the cough caused by mixture of histamine and acetylcholine in normal guinea pigs but had no effect on the cough caused by ammoniacal smoke in mices(P>0.05).The inhibitive rate of PCA in mices was 32.79%.POT could significantly prolog the latent period of expiratory dyspnea,tic and falling down caused by egg albumin in sensitized guinea pigs(P<0.001).CONCLUSION:POT had significant antagonistic effects on the PCA in mice and lessen the symptoms of asthma of sensitized guinea pigs.