| 精神分裂症和抑郁症患者体感诱发电位的初步研究 |
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| 引用本文： | 江开达,张明岛,楼翡璎,陈兴时,梁建华.精神分裂症和抑郁症患者体感诱发电位的初步研究[J].中华精神科杂志,1996(3). |
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| 作者姓名： | 江开达 张明岛 楼翡璎 陈兴时 梁建华 |
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| 作者单位： | 上海医科大学精神医学教研室，上海市精神卫生研究所电生理室 |
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| 摘 要： | 为观察精神分裂症和抑郁症患者体感诱发电位（ＳＥＰ）的变化，使用ＣＡ－１０００诱发电位叠加仪对４１例精神分裂症患者及２９例抑郁症患者ＳＥＰ进行观察，并与２５名正常人比较。结果显示，精神分裂症患者ＳＥＰ波型变异大，Ｐ２，Ｎ２及Ｐ３波潜伏期明显缩短，主波Ｐ２平均波幅较抑郁症和正常人组分别降低４０％及６３％，Ｎ１－Ｐ１，Ｐ２－Ｎ２及Ｐ３波波幅亦显著降低，与抑郁症和正常人组间均有显著或非常显著性差异。抑郁症患者Ｐ２波平均波幅比正常人组降低３０％，与正常人组有非常显著性差异。提示对ＳＥＰ作为精神科临床诊断和家系研究中易感素质筛选方面的生物学标记，值得进一步探讨
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| 关 键 词： | 精神分裂症 抑郁症 诱发电位 躯体感觉 |
Somatosensoryevokedpotentialinschizophreniaaneedpression:apreliminaryinvestigation |
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| JiangKaida,ZhangMingdao,LouFeiying,et al..Somatosensoryevokedpotentialinschizophreniaaneedpression:apreliminaryinvestigation[J].Chinese Journal of Psychiatry,1996(3). |
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| Authors: | JiangKaida ZhangMingdao LouFeiying |
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| Institution: | JiangKaida*,ZhangMingdao,LouFeiying,etal.*DepartmentofPsychologicalMedicine,ShanghaiMedicalUniversi-ty,Shanghai200032 |
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| Abstract: | Theaimofthisstudywastoobservethevariationsofsomatosensoryevokedpotentials(SEP)inschizophreniaanddepression.In41schizophrenicand29depressivepatientsaccordingtothecriteriaofChineseCategoriesofMentalDisorders,2nded,theSEPhavebeenexaminedwithCA-1000summatorandcomparedwith25normaladults.Theresultsshowedthatthewaveformsintheschizophrenicsweremorevari-ablethanthoseofthenormalsubjects.TheSEPlatencyP2,N2andP3inschizophrenicsweresignificantlyshorterthanthoseofthedepressivepatientsandnormaladults(P<0.01).ItwasshowedthattheSEPaverageamplitudeP2inschizophrenicsreduced40%and63%re-spectivelyincomparisonwiththedepres-sivepatientsandnormaladults.TheSEPamplitudesN1-P1,P2-N2andP3inschizophrenicsweresignificantlylowerthanthoseofthedepressivepatientsandnormaladults(P<0.01),whiletheSEPaverageamplitudeP2inthedepressivepatientsreduced30%incom-parisonwithnormaladults(P<0.01).ThefurtherinvestigationshouldbeconductedinordertoproveSEPcouldserveasabiologicalmarkerindiagnosingthepsychoticdisordersandscreeningforthevulner-abilitiesamongtherelevantfamilymembers. |
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| Keywords: | chizophreniaDepressionEvokedpotentials somatosensory |
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