肝动脉化疗栓塞术治疗中晚期原发性肝癌的疗效观察

目的]研究经导管肝动脉化疗栓塞术(TACE)治疗中晚期原发性肝癌的疗效并预测影响患者生存率的相关因素。方法]80例中晚期原发性肝癌患者经1次或多次TACE治疗后,分别于治疗后第1、3、6、12个月对患者进行CT扫描评估肿瘤对治疗的反应并计算生存率。结果]对所有患者随访观察3年(或者观察至死亡),80例患者共进行了163次TACE,按Child-pugh分级A级48例(60.0%),B级32例(40.0%);肿瘤大小5cm 18例(22.5%),5~10cm 42例(52.5%),10cm 20例(25.0%);行1、2、3、4次TACE的患者分别为12、56、9、3例;1、2、3年的总生存率分别为71.3%、43.8%和17.5%,肿瘤直径5cm患者TACE后3年生存率显著高于肿瘤直径为5~≥10cm患者。结论]TACE是治疗中晚期肝癌的一种有效的方法,能有效缓解患者的临床症状并延长生存期,初始肿瘤的大小是决定患者生存率的独立影响因素。

An observation of the curative effect of transcatheter arterial chemoembolization in patients with unresectable hepatocellular carcinoma

Objective] To investigate the outcome following transcatheter arterial chemoembolization （TACE）and to identify the predictors of survival in patients with unresetable hepatocellular carcinoma （HCC）. Methods] Eighty HCC patients get clinical,biochemical and radiological examination befrom TA- CE. TACE was performed in those who fulfilled the inclusion criterial follow-up assessment was done with CT scan of the liver at 1,3,6,and 12 months therapeutic effect tumor response and survival rate were estimated. Univariate analyses were done for determinations of survival. Results]eighty patients were subjected to 163 sessions of TACE. The Child＇s classification was. A 48 patients （60%）and B 32 patients （40%）. Tumor size was≤Scm in 18 （22. 5%） patients,〉5-10 cm in 42（52.5%） patients,and 〉10 cm in 20 （25 %） patients. 12,56,9,3patients were subjected to 1,2,3,4 sessions of TACE respectively, Overall survival rate was 71.3% ,43.8% and 17.5% at 1,2 and 3 years,respectively. Tumor size energed as an important predictor of survival. Conclution： TACE offers a reasonable palliative therapy for HCC. Initial tumor size is an independent predictor of survival.