三种5—羟色胺受体阻滞剂预防化疗药物所致消化道毒性的临床分析

目的探讨恩丹西酮、枢复宁、康泉预防化疗药物引起恶心呕吐的临床效果。方法采用随机对照法观察了对以顺铂为主化疗药物的止吐作用，选择病例分别为４０例、３２例及９５例。结果恩丹西酮、枢复宁、康泉对控制急性呕吐的有效率（ＣＲ＋ＰＲ）分别为：８５％、８４．４％、９６．８％，康泉与恩丹西酮、枢复宁比较均有统计学意义（Ｐ＜０．０５），而恩丹西酮与枢复宁两者比较无统计学意义（Ｐ＞０．０５）。呕吐完全控制率（ＣＲ）三者分别为６５％、７５％及８１．１％，康泉与恩丹西酮比较有统计学意义（Ｐ＜０．０５），而康泉与枢复宁及恩丹西酮与枢复宁比较均无统计学意义（Ｐ＞０．０５）。结论恩丹西酮与枢复宁对预防化疗药物引起的呕吐有效，而康泉的效果优于枢复宁及恩丹西酮。但是，康泉的价格昂贵，临床应用受到限制。

A CLINICAL ANALYSIS ON THREE KINDS OF 5HT RECEPTOR BLOCK AGENTS IN THE PROPHYLAXIS OF CHEMOTHERAPY INDUCED DIGESTIVE TRACT TOXICITY

Objective To study the antiemetic effect of ondansetronQilu,ondansetron and granisetron after receiving cisplatin. Methods In a randomized cross over trial, 40,32 and 95 patients were studied separately. Results The effective rate (CR PR) for acute emesis were 85% in patients treated with ondansetronQilu, 84.4% in those with ondansetron,and 96.8% in those with granisetron. The CR rate of emesis were 65%,75% and 81.1% in patients treated with ondansetronQilu, ondansetron and gransetron,respectively. The antiemetic effect of granisetron was higher than ondansetronQilu and ondansetron (P<0.05), but that of ondansetronQilu and ondansetron were the same (P>0.05). Conclusion The antiemetic effect of ondansetronQilu and ondansetron was good,but that of granisetron was better.