| 内皮素-1、内皮素转化酶-1和 肿瘤坏死因子-α在脂溢性角化病皮损中的表达 |
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| 引用本文： | 吴娟,盛晚香.内皮素-1、内皮素转化酶-1和 肿瘤坏死因子-α在脂溢性角化病皮损中的表达[J].中华皮肤科杂志,2009,42(2):143. |
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| 作者姓名： | 吴娟 盛晚香 |
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| 作者单位： | 武汉大学中南医院皮肤科,430071 |
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| 摘 要： | 目的: 探讨内皮素-1（ET-1）、内皮素转换酶-1( ECE-1)和肿瘤坏死因子-α（TNF-α）在脂溢性角化病(seborrheic keratosis , SK) 皮损出现色素沉着的发病机制。方法: 采用免疫组化SP 法检测30 例脂溢性角化病(SK) 皮损组织中ET-1、ECE-1和 TNF-α的表达,并选用10 例正常皮肤组织作为对照。结果:SK组中ET-1、ECE-1和 TNF-α的阳性表达程度分别显著高于对照组。结论: SK组织中存在ET-1、ECE-1和 TNF-α的过度表达,这种异常高表达的ECE-1和 TNF-α可能通过参与脂溢性角化病(SK)的自分泌生长环路而上调ET-1的表达，并且与脂溢性角化病(SK)的色素沉着有关。
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| 收稿时间： | 2008-02-26 |
| 修稿时间： | 2008-03-25 |
Expression of endothelin-1, endothelin converting enzyme and tumor necrosis factor-α in seborrheic keratosis |
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| Abstract: | Objective: To investigate the expression of ET-1、ECE-1 and TNF-α in pathogenesis of seborrheic keratosis (SK) . Methods: The ET-1、ECE-1 and TNF-α expression in sit u in 30 cases of SK and 10 cases of normal skin tissue were examined by immunohisto-chemistry assay. Results : The expressive intensity of ET-1、ECE-1 and TNF-αin the SK group was significantly higher than that in the controls. Conclusions: These findings suggest that the increased secretion of ET-1 leading to enhanced pigmentation in SK results from the co-ordinated increased expression of TNF-α and ECE-1. |
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