心房颤动患者心型脂肪酸结合蛋白检测的临床价值

目的： 评价定量检测血清心型脂肪酸结合蛋白(heart type-fatty acid binding protein，H-FABP)对心房颤动患者检测的临床价值。方法： 采用酶联免疫吸附试验一步夹心法检测196名健康体检者、196例心房颤动患者的血清H-FABP，同时测定心肌肌钙蛋白I(cardiac troponin I，cTnI)、肌酸激酶同工酶-MB (creatine kinase isoenzyme MB，CK-MB)，并作比较。结果： 房颤组治疗前、治疗后及对照组的H-FABP值分别为（2.8±1.3）μg/L，（2.3±1.4）μg/L和（1.6±1.1）μg/L；cTnI值分别为（0.26±0.05）μg/L，（0.23±0.06）μg/L和（0.05±0.02）μg/L；CK-MB值分别为(12.8±3.6) U/L，(13.6±3.1)U/L和(12.1±2.7) U/L。血浆H-FABP水平房颤组治疗前、治疗后及与对照组比较，差异均有统计学意义(P<0.05)；血浆cTnI水平在房颤治疗前、治疗后比较差异无统计学意义(P>0.05)，与对照组比较差异有统计学意义（P<0.05）；血浆CK-MB水平房颤组治疗前、治疗后及与对照组比较差异均无统计学意义(P>0.05)。结论： 检测血清H-FABP对心房颤动患者有较重要的临床价值。

Clinical value of detection of heart type-fatty acid binding protein on evaluating the patients with atrial fibrillation

Objective: To test the value of detection of heart type-fatty acid binding protein(H-FABP) on evaluating the patients with atrial fibrillation.Methods: H-FABP was measured in 196 healthy persons and 196 patients with atrial fibrillation by ELISA one-step sandwich assay,at the same time,creatine kinase isoenzyme-MB(CK-MB)and cardiac troponin I(cTnI) were determined.Results: The value of H-FABP in patients before treatment with atrial fibrillation,patients with atrial fibrillation after treatment,healthy persons were(2.8±1.3) μg/L,(2.3±1.4) μg/L,(1.6±1.1) μg/L;the value of cTnI were(0.26±0.05) μg/L,(0.23±0.06) μg/L,(0.05±0.02) μg/L;and the value of CK-MB were(12.8±3.6) U/L,(13.6±3.1) U/L,(12.1±2.7) U/L.There was significant difference in H-FABP level between patients before treatment,patients after treatment,healthy persons(P<0.05).There was no significant difference in cTnI level between patients before treatment and patients after treatment(P>0.05).There was significant difference in cTnI level between patients with atrial fibrillation and healthy persons(P<0.05).There was no significant difference in CK-MB level between patients before treatment,patients after treatment,healthy persons(P>0.05).Conclusion: Serum H-FABP to patients with atrial fibrillation who tested have an important clinical value.