伊班膦酸钠预防与治疗糖皮质激素诱导的骨质疏松症

目的 探讨伊班膦酸钠(IBA)在糖皮质激素引起的家兔骨质丢失中的预防与治疗作用.方法 60只家兔随机分为:对照组1和2(注射生理盐水)、DX6组(注射地塞米松,连续6周)、预防组(注射地塞米松前注射1次IBA)、DX12组(注射地塞米松,连续12周)和治疗组(注射地塞米松6周后,注射1次IBA).6周末,将对照组1、DX6组和预防组家兔处死;12周末将剩余组家兔处死.结果 预防组家兔腰椎骨小梁面密度、厚度、数量比DX6组分别增加了100.00%、40.55%和45.66%(P<0.01),治疗组家兔比DX12组分别增加了73.34%、23.87%和39.02%(P<0.05).预防组家兔腰椎压缩和股骨3点弯曲最大负荷及肱骨扭转最大扭矩比DX6组分别增加了24.19%、29.91%和37.24%(P<0.01),治疗组家兔比DX12组分别增加了54.36%、21.38%和105.75%(P<0.05).结论 IBA可有效预防和治疗糖皮质激素引起的家兔骨质丢失和骨强度的下降.

Ibandronate preventing and treating glucocorticiod-induced osteoporosis in rabbits

Objective To evaluate the efficacy of ibandronate (IBA) in prevention and treatment of glucocorticoid-induced osteoporosis in rabbits. Methods Sixty New Zealand white rabbits were randomly allocated into six groups: control-1 group, control-2 group (treated with saline), DX6 group (treated with dexamethasone for 6 weeks), prevention group (injected with IBA at a dose of 2mg/kg before dexamethasone treatment), DX12 group (treated with dexamethasone for 12 weeks) and treatment group (additionally received IBA injection after dexamethasone treatment for 6 weeks). The rabbits from control-1 group, DX6 group and prevention group were sacrificed at week 6 and the rabbits from remaining groups were sacrificed at week 12 for bone biomechanical analysis and histological examination. Results Compared with DX6 group, bone volume/tissue volume (BV/TV), trabecular number (Tb.N) and trabecular thickness (Tb.Th) of the lumbar spine in the prevention group increased by 100%, 45.74% and 40.55%, respectively (EM>P/EM> <0.01). The parameters in the treatment group increased by 73.34%、23.87% and 39.02%, respectively (EM>P/EM> <0.05), comparing with DX12 group. The maximum compressive load, the maximum bending stress and the maximum torque of the prevention group were higher than DX6 group by 24.19%, 29.91% and 37.24 %, respectively (EM>P /EM><0.01). The biomechanical parameters of the treatment group were higher than DX12 group by 54.36%, 21.38%, 105.75%, respectively (EM>P/EM> <0.05). Conclusion IBA may effectively prevent and treat glucocorticoid induced loss of bone mass and str