| 富硒益生菌的急性毒性和遗传毒性试验 |
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| 引用本文： | 秦顺义,黄克和. 富硒益生菌的急性毒性和遗传毒性试验[J]. 癌变．畸变．突变, 2007, 19(2): 96-98. DOI: 10.3969/j.issn.1004-616X.2007.02.004 |
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| 作者姓名： | 秦顺义 黄克和 |
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| 作者单位： | 南京农业大学动物医学院,江苏,南京,210095 |
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| 基金项目： | 国家自然科学基金项目（30371060;30671547）;江苏省自然科学基金（BK2006144） |
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| 摘 要： | 背景与目的:研究富硒益生菌的急性毒性和遗传毒性.材料与方法:采用小鼠急性毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验和小鼠精子畸形试验等对富硒益生菌进行安全性试验研究.结果:急性毒性试验表明,小鼠灌胃给予富硒益生菌,其LD50为18.49 g/kg.Ames试验、微核试验和精子畸形试验结果均为阴性.结论:在本次实验条件下,富硒益生菌表现出一定的急性毒性,但未见遗传毒性.由此可初步判定,在人体推荐摄入剂量每天50 mg范围内使用富硒益生菌是安全可靠的.
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| 关 键 词： | 富硒益生菌 急性毒性 Ames试验 微核试验 精子畸形试验 |
| 文章编号： | 1004-616X（2007）02-0096-03 |
| 收稿时间： | 2006-08-31 |
| 修稿时间： | 2006-12-08 |
Acute Toxicity and Genotoxicity Tests of Selenium-enriched Probiotics |
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| QIN Shun-yi,HUANG Ke-he. Acute Toxicity and Genotoxicity Tests of Selenium-enriched Probiotics[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2007, 19(2): 96-98. DOI: 10.3969/j.issn.1004-616X.2007.02.004 |
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| Authors: | QIN Shun-yi HUANG Ke-he |
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| Affiliation: | College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China |
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| Abstract: | BACKGROUND & AIM: To study the acute toxicity and genotoxicity of selenium-enriched probiotics. MATERIALS AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice, sperm abnormality test of mice were used. RESULTS: The oral acute toxicity study revealed that the LD50 of selenium-enriched probiotics was 18.49 g/kg in mice. The results of genotoxicity tests were all negative, including Ames test, micronucleus test and sperm shape abnormality test. CONCLUSION: Selenium-enriched probiotics showed certain toxicity but no genotoxicity in this study. Thus,selenium-enriched probiotics was safe at the daily-recommended dose(50 mg/person/day) and has the potential for development into functional foods. |
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| Keywords: | selenium-enriched probiotics acute toxicity Ames test micronucleus test sperm abnormality test |
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