| PCNA在乳腺病变组织中的表达与病理学特性关系 |
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| 引用本文： | 赵瑾,李峰,李洪安,张国昌,郑玉琴. PCNA在乳腺病变组织中的表达与病理学特性关系[J]. 农垦医学, 1995, 0(2) |
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| 作者姓名： | 赵瑾 李峰 李洪安 张国昌 郑玉琴 |
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| 作者单位： | 石河子医学院病理学教研室 |
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| 摘 要： | 本文运用增殖细胞核抗原(PCNA)单克隆抗体对88例乳腺病变组织进行免疫组化研究,并与乳腺癌组织学分级和淋巴结转移作了对比分析,结果显示:乳腺良性病变阳性率为16%,乳腺癌为73.02%,两者比较有显著性差异P<0.01),pCNA指数与乳腺癌组织学分级淋巴结转移密切相关.作者认为PCNA的表达对区分良恶性病变及组织学分级,淋巴(?)转移(?)为客观可靠,是(?)癌预后判断的良好指标.
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| 关 键 词： | 增殖细胞核抗原 乳腺癌 预后 |
PCNA ASSESSMENT OF BREAST LESION AND ITS PATHOGENICAL CHARACTERISTICS |
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| Zhao Jin Li Fang Li Hongan Zhang Guo chang Zhen Yuqin. PCNA ASSESSMENT OF BREAST LESION AND ITS PATHOGENICAL CHARACTERISTICS[J]. Agricultural Reclamation Medicine, 1995, 0(2) |
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| Authors: | Zhao Jin Li Fang Li Hongan Zhang Guo chang Zhen Yuqin |
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| Affiliation: | Zhao Jin Li Fang Li Hongan Zhang Guo chang Zhen Yuqin Department of pathology,shihezi Medical College Xin Jiang 832002 |
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| Abstract: | An immunochemical study on 88 cases of breast lesion with proliferating Cell nuclear antigen (PCNA) and monoclonal antibody was carried out and compared with his-tograding of breasrt carcinoma and analysis of lymphatic metastasis. The result indicates:the positive rate of benign breast lesion is 16% , breast carcinoma 73. 02% with a significant dif-ference (P<0.01). It revealed a close relationship between the PCNA index and the his-tograding of breast carcinoma, and lymphatic metastasis. The authors suggest that PCNA assessment is objective, dependable in differentiating benign breast lesion from the malignat lesion and histograding, lymphatic metastasis. It is an adoptable index for the prognosis of breast carcinoma |
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| Keywords: | proliferating cell nuclear antigen (PCNA) breast carcinoma prognosis |
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