| 美满霉素抑制血管性认知功能损伤大鼠海马星型胶质细胞激活和神经炎症(英文) |
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| 引用本文： | 蔡志友,晏勇,陈然. 美满霉素抑制血管性认知功能损伤大鼠海马星型胶质细胞激活和神经炎症(英文)[J]. 中国神经科学杂志, 2010, 0(1) |
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| 作者姓名： | 蔡志友 晏勇 陈然 |
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| 作者单位： | 安徽省六安市人民医院神经内科;安徽医科大学第五临床学院;重庆医科大学附属第一医院神经内科;重庆市神经病学重点实验室; |
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| 基金项目： | supported in part by High Technology Research Center, Chongqing Medical University and the Ministry of Civil Affairs,China. |
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| 摘 要： | 目的观察美满霉素(minocycline)对血管性认知功能损伤大鼠海马组织GFAP、COX-2、NF-κB、IL-1β和TNF-α表达的影响,探讨美满霉素对血管性认知功能损伤脑保护作用的机制。方法Wistar大鼠随机分为假手术组(S组)、血管性认知功能损伤模型组(M组)和美满霉素治疗组(MT组)。免疫组织化学法检测大鼠海马组织COX-2和NF-κB的表达,蛋白质印迹和免疫组织化学法检测大鼠海马组织GFAP的表达,ELISA法检测大鼠海马组织IL-1β和TNF-α的表达。结果MT 组 GFAP、COX-2、NF-κB、IL-1β和 TNF-α表达较 M 组均降低(P<0.01) ;MT 和 M 组GFAP、COX-2、NF-κB、IL-1β和 TNF-α表达均显著高于 S 组(P<0.01)。结论美满霉素能降低血管性认知功能损伤大鼠海马组织中GFAP、COX-2、NF-κB、IL-1β和TNF-α的表达,抑制血管性认知功能损伤大鼠海马星型胶质细胞活化和神经炎症,发挥脑保护作用。
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| 关 键 词： | 血管性认知功能损伤 美满霉素 炎症 星型胶质细胞 |
Minocycline reduces astrocytic reactivation and neuroinflammation in the hippocampus of a vascular cognitive impairment rat model |
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| Zhi-You CAI,Yong YAN,Ran CHEN. Minocycline reduces astrocytic reactivation and neuroinflammation in the hippocampus of a vascular cognitive impairment rat model[J]. Neuroscience Bulletin, 2010, 0(1) |
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| Authors: | Zhi-You CAI Yong YAN Ran CHEN |
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| Affiliation: | Zhi-You CAI1,Yong YAN2,Ran CHEN1 1Department of Neurology,Lu'an People's Hospital,the Fifth Clinical College,Anhui Medical University,Lu'an 237005,China 2Department of Neurology,the First Affiliated Hospital,Chongqing Medical University,Chongqing Key Laboratory of Neurology,Chongqing 400016,China |
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| Abstract: | Objective To study the neuroprotective mechanism of minocycline against vascular cognitive impairment after cerebral ischemia. Methods The rat model with vascular cognitive impairment was established by permanent bilateral common carotid artery occlusion (BCCAO). The observing time-points were determined at 4, 8 and 16 weeks after BCCAO. Animals were randomly divided into sham-operated group (n = 6), model group (subdivided into 3 groups: 4 weeks after BCCAO, n = 6; 8 weeks after BCCAO, n = 6; and 16 weeks ... |
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| Keywords: | vascular cognitive impairment minocycline inflammation astrocyte |
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