Postnatal development of the organ of Corti in cats: a light microscopic morphometric study |
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| Institution: | 1. Department of Otolaryngology, Epstein Laboratory – U490, University of California at San Francisco, San Francisco, CA 94143-0526, USA;2. Dept. of Otolaryngology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160, Japan;1. CAS Key Laboratory of Mineralogy and Metallogeny/Guangdong Provincial Key Laboratory of Mineral Physics and Materials, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, 511 Kehua Street, Guangzhou 510640, China;2. College of Resources and Environment, Yangtze University, Wuhan 430100, China;3. Geosciences Department, University of Wisconsin-Parkside, Kenosha, WI 53141, USA;1. Department of Chemistry, Anna University Regional Campus-Tirunelveli, Tirunelveli-627 007, Tamil Nadu, India;2. Post Graduate and Research Department of Chemistry, Vivekananda College, Tiruvedakam West- 625234, Madurai District, Tamil Nadu, India;3. Department of Chemistry, PSNA College of Engineering & Technology, Dindigul, Tamil Nadu, India;4. School of Chemistry, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India;5. K.L.N College of Information Technology, Pottapalayam, Sivagangai-630 611, Tamil Nadu, India;1. School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China;2. Key Lab of Biometallurgy of Ministry of Education of China, Central South University, Changsha 410083, China;3. Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;4. Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, China |
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| Abstract: | This study quantitatively characterizes the development of the major morphological features of the organ of Corti during the first 2 weeks postnatal, the period when the cat auditory system makes the transition from being essentially non-functional to having nearly adult-like responses. Four groups of kittens (n=3) were studied at one day postnatal (P1), P5, P10, P15, and compared to adults. Measurements were made of the organ of Corti at 3 cochlear locations: 20%, 60% and 85% of basilar membrane length from the base – cochlear locations which in the adult correspond to best frequencies of ≈20 kHz, 2 kHz and 500 Hz, respectively. In addition, measurements of basilar membrane length and opening of the tunnel of Corti were made in 20 cochlear specimens from kittens aged P0–P6. Results indicate that: (i) at P0 the basilar membrane has attained adult length, and the tunnel of Corti is open over approximately the basal one-half of the cochlea; (ii) the initial opening of the tunnel of Corti occurs at a site about 4 mm from the cochlear base (best frequency of ≈25 kHz in the adult cochlea); (iii) the thickness of the tympanic cell layer decreases markedly at the basal 20-kHz location; (iv) the areas of the tunnel of Corti and space of Nuel and the angulation of the inner hair cells (IHC) relative to the basilar membrane all show marked postnatal increases at both the middle and apical locations; (v) IHC are nearly adult-like in length and shape at birth, whereas the OHC (at 2-kHz and 500-Hz locations) undergo marked postnatal changes; (vi) disappearance of the marginal pillars and maturation of the supporting cells are not yet complete by P15. |
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