| 上海市崇明地区幽门螺杆菌耐药性分析及cagA基因检测 |
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| 引用本文： | 谢国艳,高志生,周建华,蔡志昌,黄敏,胡嘉波. 上海市崇明地区幽门螺杆菌耐药性分析及cagA基因检测[J]. 中国感染与化疗杂志, 2008, 8(6): 463-465 |
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| 作者姓名： | 谢国艳 高志生 周建华 蔡志昌 黄敏 胡嘉波 |
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| 作者单位： | [1]上海交通大学医学院附属仁济医院崇明分院检验科,202150 [2]江苏大学医学技术学院,202150 |
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| 基金项目： | 上海市崇明县县科委课题 |
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| 摘 要： | 目的探讨上海市崇明地区含细胞毒素相关基因A（cagA）的幽门螺杆菌（Hp）的感染情况及cagA基因与Hp的耐药性关系。方法对150株临床分离菌株，采用PCR法检测Hp的cagA基因，同时采用纸片扩散法作药敏试验。结果崇明地区Hp对甲硝唑、替硝唑、阿莫西林、克拉霉素、阿奇霉素和呋喃唑酮的耐药率分别为32%、10、2、0、0和0。78．7％的Hp菌株含有cagA基因。结论本地区阿莫西林、阿奇霉素、呋喃唑酮可作为根除Hp的首选药物。本地区Hp感染以Ⅰ型菌株为主，含cagA基因Hp菌株对甲硝唑耐药率明显低于不含cagA基因Hp菌株。
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| 关 键 词： | 幽门螺杆菌 cagA基因 聚合酶链反应 耐药性 |
The antibiotic resistance and prevalence of cagA gene in the Helicobacter pylori strains isolated from Chongming,Shanghai |
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| XIE Guo-yan,GAO Zhi-sheng,ZHOU Jian-hua,CAI Zhi-chang,HUANG min,HU Jia-bo.. The antibiotic resistance and prevalence of cagA gene in the Helicobacter pylori strains isolated from Chongming,Shanghai[J]. Chinese Journal of Infection and Chemotherapy, 2008, 8(6): 463-465 |
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| Authors: | XIE Guo-yan GAO Zhi-sheng ZHOU Jian-hua CAI Zhi-chang HUANG min HU Jia-bo. |
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| Affiliation: | XIE Guo-yan,GAO Zhi-sheng,ZHOU Jian-hua,CAI Zhi-chang,HUANG min,HU Jia-bo. (Department of Clinical Laboratory,Chongming Branch of Renji Hospital,Shanghai Jiaotong University,Shanghai 202150,China) |
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| Abstract: | Objective To investigate the prevalence of cagA gene and the relationship between cagA gene and antibiotic resistance in Helicobacter pylori in Chongming,Shanghai.Methods A total of 150 H. pylori isolates were tested for cagA gene by PCR. The susceptibility testing was done by disk diffusion technique.Results The percentage of H. pylori isolates resistant to metronidazole,tinidazole,amoxicillin,clarithromycin,azithromycin,furazolidone was 32%,10%,2%,0,0,0,respectively. The prevalence of cagA gene in H. pylo... |
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| Keywords: | Helicobacter pylori cagA gene Polymerase chain reaction Resistance |
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