BK transplant nephropathy successfully treated with cidofovir. |
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| Authors: | Lisa S Keller Chen Au Peh James Nolan Kym M Bannister Anthony R Clarkson Randall J Faull |
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| Institution: | Department of Renal Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, SA 3000, Australia. lkeller@mail.rah.sa.gov.au |
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| Abstract: | |
Introduction
| BK-virus-induced interstitial nephritis (BK nephropathy) isa recently recognized condition affecting renal allografts thatmay lead to graft failure 1]. BK-virus infection is endemicworldwide with seroprevalence rates in normal adults of 60–80%1]. Risk factors for BK nephropathy include high levels ofimmunosuppression, particularly involving tacrolimus 2]. Thereis no established treatment other than reduction of immunosuppressionto aid viral clearance, which risks acute irreversible rejection3]. There are in vitro data showing that cidofovir inhibitsBK virus replication, but there are
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| Keywords: | BK transplant nephropathy BK virus cidofovir renal transplant |
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