对比老年ST段抬高型急性心肌梗死患者应用不同剂量替格瑞洛联合瑞替普酶治疗的临床效果

目的 分析对老年ST段抬高型急性心肌梗死患者应用不同剂量替格瑞洛联合瑞替普酶治疗的临床效果.方法 90例老年ST段抬高型急性心肌梗死患者,采用随机数字表法分为对照组及观察组,每组45例.两组患者均接受阿司匹林与瑞替普酶治疗,对照组给予常规剂量替格瑞洛治疗,观察组给予负荷剂量替格瑞洛治疗.对比两组患者的血管再通率、治疗前...

Clinical effect of different doses of ticagrelor and reteplase in elderly patients with ST-segment elevation acute myocardial infarction

Objective To analyze the clinical effect of different doses of ticagrelor and reteplase in elderly patients with ST-segment elevation acute myocardial infarction. Methods A total of 90 elderly patients with ST-segment elevation acute myocardial infarction were divided into control group and observation group by random numerical table, with 45 cases in each group. Both groups received aspirin and reteplase. On this basis,the control group was treated with conventional doses of ticagrelor, and the observation group was treated with loading doses of ticagrelor. Both groups were compared in terms of vascular recanalization rate, changes of platelet parameters [plateletcrit(PCT), mean platelet volume(MPV), platelet count(PLT)] before and after treatment, as well as the occurrence of bleeding and dyspnea after treatment. Results At 1.0, 1.5, and 2.0 h after treatment,the vascular recanalization rates of the observation group were 51.11%, 80.00%, and 93.33%, which were higher than 28.89%, 44.44%, and 55.56% of the control group, and the difference was statistically significant(P<0.05).After treatment, there was no statistically significant difference in PCT between the two groups(P>0.05). After treatment, the MPV(12.00±0.71) fl of the observation group was higher than(9.69±0.60) fl of the control group,and the PLT(139.66±17.65)×10⁹/L was lower than(239.43±18.99)×10⁹/L of the control group, and the difference was statistically significant(P<0.05). There was no statistically significant difference in the incidence of bleeding and dyspnea between the two groups(P>0.05). Conclusion The treatment of the elderly patients with ST-segment elevation acute myocardial infarction with ticagrelor and reteplase can effectively improve the vascular recanalization rate and shorten the recanalization time, improve the platelet parameters and therapeutic effect, which has a high clinical application value.