氟西汀联合抗精神病药物治疗伴有强迫症状的精神分裂症的效果研究

目的 分析氟西汀联合抗精神病药物治疗伴有强迫症状的精神分裂症的效果.方法 70例伴有强迫症状的精神分裂症患者,根据随机数字表法分为观察组与对照组,每组35例.对照组患者给予抗精神病药物治疗,观察组患者在对照组基础上增加氟西汀治疗.比较两组强迫症状改善时间、住院时间,治疗前后阳性和阴性症状量表(PANSS)评分、耶鲁-布...

Effect of fluoxetine combined with antipsychotics on schizophrenia with obsessive-compulsive symptoms

Objective To analyze the effect of fluoxetine combined with antipsychotics on schizophrenia with obsessive-compulsive symptoms. Methods A total of 70 cases of schizophrenia with obsessive-compulsive symptoms were randomly divided into observation group and control group, with 35 cases in each group. Patients in the control group were treated with antipsychotics, and patients in the observation group were treated with fluoxetine on the basis of the control group. Both groups were compared in terms of improvement time of obsessivecompulsive symptoms, hospitalization time, positive and negative symptom scale(PANSS) score before and after treatment, Yale-Brown obsessive-compulsive scale(YBOCS) score, Hamilton anxiety scale score, quality of life score, clinical efficacy, and occurrence of adverse reactions. Results The improvement time of obsessivecompulsive symptoms(6.68±1.27) d and hospitalization time(8.98±2.67) d in the observation group were shorter than(9.78±2.75) and(12.56±3.34) d in the control group, and the difference was statistically significant(P<0.05).After treatment, the PANSS score, YBOCS score, Hamilton anxiety scale score, and quality of life score of the two groups were improved compared to those of this group before treatment. The PANSS score, YBOCS score, and Hamilton anxiety scale score of the observation group were lower than those of the control group, and the quality of life score was higher than that of the control group. All the differences were statistically significant(P<0.05).The total effective rate of treatment 94.29%(33/35) in the observation group was higher than 74.29%(26/35) in the control group, and the difference was statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 20.00%(7/35), which was not statistically significant compared with 22.86%(8/35) in the control group(P>0.05). Conclusion Antipsychotics combined with fluoxetine are effective in the treatment of schizophrenia with obsessive-compulsive symptoms, and can better improve patients’ condition and quality of life.