功能性磁共振成像在轻度认知障碍检测诊断的研究综述

现代社会中,阿尔茨海默病已经成为严重影响和限制个人日常生活甚至危及患者生命安全的一种疾病.轻度认知障碍作为阿尔茨海默病的前一个阶段,对其精确诊断有助于干预或降低患者转化为阿尔茨海默病的几率.目前,功能磁共振成像技术已经广泛应用于轻度认知障碍的检测诊断研究中.从特征提取、特征选择、数据降维和分类识别等方面,对fMRI在M...

Review of Functional Magnetic Resonance Imagingin Diagnosis of Mild Cognitive Impairment

Nowadays Alzheimer's disease (AD) has severely influenced and limited personal daily life and even posed a grave threat to the life and health of patients. Mild cognitive impairment (MCI) is the prodromal stage of AD, and accurate diagnosis can help to interfere or reduce the conversion of patients to Alzheimer's disease. At present, functional magnetic resonance imaging (fMRI) technology have been widely used in the detection and diagnosis of MCI. This article introduced the research status of fMRI in MCI from the aspects of feature extraction, feature selection, data dimensionality reduction and classification recognition. First, the commonly used resolution indicators such as low-frequency amplitude, local consistency, and functional connection for feature extraction was introduced. Second, features selection and data dimension reduction methods were introduced, and the efficient machine learning and deep learning algorithms in classification and recognition were summarized. This paper also proposed the remained problems and made perspectives to the future research.