RF酰胺相关肽3调节雌性哺乳动物生殖活动的研究进展

雌性哺乳动物的生殖受下丘脑-垂体-卵巢(hypothalamus-pituitary-ovary,HPO)轴调控,外周和中枢的诸多刺激因子参与其中并组成复杂的调节网络.哺乳动物下丘脑神经肽RF酰胺相关肽3(RFamide-related peptide 3,RFRP-3)是下丘脑中的HPO轴抑制因子,通过G蛋白耦联受体...

Advances in RFRP-3 Regulates Reproduction in the Female Mammal

Reproduction of female mammals is regulated by a complex network of the hypothalamic-pituitary-ovarian (HPO) axis integrated with peripheral and central stimulators. RFamide-related peptide 3 (RFRP-3), a kind of mammalian hypothalamic neuropeptide, is a inhibitor of HPO axis in the mammalian hypothalamus. RFRP-3 plays major physiological roles by binding to its specific receptor, G protein-coupled receptor 147 (GPR147). It can synergistically affect mating behavior and reproductive activities of mammals with other neuropeptides. In addition, RFRP-3 can regulate hypothalamus energy homeostasis signal. However, there is no consensus on the main determinants of endogenous role of RFRP-3 in metabolic homeostasis and reproductive activity in female mammals. In this paper, we review the effects of RFRP-3 on energy balance, stress regulation and reproductive function in female mammals, in order to provide new insights into the mechanisms and therapeutic interventions of reproductive and metabolic diseases.