Elevated neutrophil to lymphocyte ratio is associated with poor long-term survival and graft failure after lung transplantation |
| |
| Authors: | Aravind Krishnan Joshua Hsu Jinny S. Ha Stephen R. Broderick Pali D. Shah Robert SD. Higgins Christian A. Merlo Errol L. Bush |
| |
| Affiliation: | 1. Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, USA;2. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, USA;1. Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA;2. Division of Plastic and Reconstructive Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA;3. Division of Plastic and Reconstructive Surgery, Baylor Scott & White Medical Center, Temple, TX, USA;1. Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md;2. Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Md;3. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Md;4. Divisions of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md;5. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Md;1. Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York;2. the Heart Center, Juntendo University School of Medicine, Tokyo, Japan;3. Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York. |
| |
| Abstract: | PurposeWe aimed to assess the prognostic value of Neutrophil to Lymphocyte Ratio (NLR) on long-term outcomes and graft dysfunction after lung transplantation.MethodsWe retrospectively reviewed all patients receiving a lung transplant at our institution from 2011 to 2014. The primary exposure was elevated NLR at the time of transplant, defined by NLR>4. The primary outcomes were graft failure and three-year all-cause mortality. Multivariate logistic regression and Kaplan-Meier survival analysis were used to analyze outcomes.Results95 patients were included. 40 patients (42%) had an elevated NLR. Elevated NLR was associated with graft failure (OR: 4.7 [1.2–18.8], p = 0.02), and three-year mortality (OR: 5.4 [1.3–23.2], p = 0.03) on multivariate logistic regression. Patients with elevated NLR demonstrated significantly lower survival on Kaplan-Meier analysis (50% versus 74%, p = 0.02). The c-statistic for our multivariate model was 0.91.ConclusionElevated neutrophil to lymphocyte ratio is associated with poor long-term survival and graft failure after lung transplantation. |
| |
| Keywords: | Transplantation Lung transplantation Immunology Biomarker Outcomes |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
