补气畅络方治疗气虚血瘀型冠心病慢性心衰的临床效果及对炎症因子的影响探究

目的分析补气畅络方治疗气虚血瘀型冠心病慢性心力衰竭(慢性心衰,CHF)的临床效果及对患者炎症因子的影响。方法106例气虚血瘀型冠心病CHF患者,根据治疗方案不同分为西药组与补气组,每组53例。西药组予以常规西药治疗,补气组在西药组基础上加用补气畅络方治疗。分析比较两组中医证候积分、心功能指标左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、心输出量(CO)]及炎症因子超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)]水平。结果治疗前,两组的中医证候积分比较差异无统计学意义(P>0.05);治疗后,补气组的中医证候积分(7.14±1.01)分低于西药组的(14.31±2.00)分,差异具有统计学意义(P<0.05)。治疗后,补气组的LVEF(50.11±4.67)%、CO(5.53±1.30)L/min均高于西药组的(45.63±3.60)%、(4.27±1.04)L/min,LVEDD(55.44±1.38)mm小于西药组的(60.10±2.44)mm,差异具有统计学意义(P<0.05)。治疗后,补气组的hs-CRP(4.57±1.40)mg/L、TNF-α(14.22±2.10)ng/L及IL-6(4.00±0.75)ng/L均低于西药组的(6.50±1.67)mg/L、(18.67±2.63)ng/L、(5.63±1.39)ng/L,差异具有统计学意义(P<0.05)。结论补气畅络方治疗气虚血瘀型冠心病CHF疗效较好,可明显改善患者的临床症状及心功能,同时减轻炎症反应,利于恢复。

Clinical effect of Buqi Changluo Recipe on chronic heart failure of coronary heart disease with Qi-deficiency and blood-stasis syndrome and its influence on inflammatory factors

Objective To analyze the clinical effect of Buqi Changluo Recipe on chronic heart failure of coronary heart disease(CHF)with Qi-deficiency and blood-stasis syndrome and its influence on inflammatory factors.Methods A total of 106 CHF patients with coronary heart disease with Qi deficiency and blood stasis syndrome were divided into western medicine group and Qi-invigorating group according to different treatment plans,with 53 cases in each group.The western medicine group was treated with conventional western medicine,and the Qi-invigorating group was treated with Buqi Changluo Recipe on the basis of the western medicine group.Both groups were analyzed and compared in terms of TCM syndrome score,cardiac function indexesleft ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),cardiac output(CO)]and inflammatory factorshigh-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)].Results Before treatment,there was no statistically significant difference in TCM syndrome score between the two groups(P>0.05).After treatment,the TCM syndrome score(7.14±1.01)points of the Qi-invigorating group was lower than(14.31±2.00)points of the western medicine group,and the difference was statistically significant(P<0.05).After treatment,the LVEF(50.11±4.67)%and CO(5.53±1.30)L/min of the Qi-invigorating group were higher than(45.63±3.60)%and(4.27±1.04)L/min of the western medicine group,and the LVEDD(55.44±1.38)mm was less than(60.10±2.44)mm in the western medicine group,and the difference was statistically significant(P<0.05).After treatment,the hs-CRP(4.57±1.40)mg/L,TNF-α(14.22±2.10)ng/L and IL-6(4.00±0.75)ng/L in the Qi-invigorating group were lower than(6.50±1.67)mg/L,(18.67±2.63)ng/L,and(5.63±1.39)ng/L in the western medicine group,and the difference was statistically significant(P<0.05).Conclusion Buqi Changluo Recipe has good efficacy in the treatment of chronic heart failure of CHF with Qi-deficiency and blood-stasis syndrome,which can significantly improve the clinical symptoms and cardiac function of patients,as well as reduce the inflammatory response and facilitate recovery.