基于MRI的精神分裂症阴性症状脑影像研究进展

慢性精神分裂症患者临床表现上常以阴性症状为主,也是精神残疾的主要因素,极大影响了患者的生存质量.迄今为止,阴性症状产生神经机制仍然不明晰,导致其难以被有效控制.对近年来阴性症状相关脑影像研究进行综述,包括以丘脑和纹状体为主的皮层下区域的受损与精神分裂症的发生,皮层下-皮层回路异常与精神分裂症阴性症状等.对拓扑连接这一新...

Neuroimaging Research Progress of Negative Symptoms in Schizophrenia

Patients with chronic schizophrenia have negative symptoms as the main clinical manifestations, which are also the main factor of mental disability, has a great effect on the life quality of patients. So far, the neural mechanism of negative symptoms is still unclear, making it hard to be controlled. This article reviewed the research progress in different aspects in this field, including the occurrence of schizophrenia associated to the damage of subcortical regions (the striatum and thalamus), and the abnormality of the subcortex-cortical connectivity associated to negative symptoms. This article also proposed the perspectives of the new method (reconstruction of topological brain connection) in the study of the mechanism of negative symptoms of schizophrenia, such as exploring the coupling of the dopaminergic neurotransmitter system of the striatum-thalamus-prefrontal loop, and the deconstruction of spatial distribution information. In addition, the application of deep learning can further decode the topological features of the critical brain connections relate to negative symptoms, which is expected to become a potentially approach to explore the mechanism of negative symptoms of schizophrenia.