奥曲肽联合奥美拉唑治疗轻度上消化道出血的临床观察

目的评价奥曲肽与奥美拉唑联合治疗轻度上消化道出血的可行性,为消化科疾病治疗工作提供参考。方法80例轻度上消化道出血患者,随机分为对照组和观察组,每组40例。对照组采用奥美拉唑治疗,观察组采用奥美拉唑+奥曲肽治疗。比较两组患者临床疗效、不良反应发生情况(恶心、腹胀、头痛等)、大便隐血转阴时间、止血时间、住院时间、血小板计数、活化部分凝血活酶时间(APTT)。结果观察组治疗总有效率97.50%高于对照组的80.00%,差异具有统计学意义(P<0.05)。观察组不良反应发生率7.50%与对照组的5.00%比较,差异无统计学意义(P>0.05)。观察组患者大便隐血转阴时间(2.10±0.50)d、止血时间(18.50±3.50)h、住院时间(5.20±1.30)d、APTT(27.12±4.20)s均短于对照组的(5.20±0.50)d、(37.50±4.50)h、(8.30±1.50)d、(33.50±4.50)s,血小板计数(155.50±10.50)×10⁹/L高于对照组的(132.20±9.30)×10⁹/L,差异均具有统计学意义(P<0.05)。结论轻度上消化道出血患者应用奥曲肽+奥美拉唑治疗助于改善患者临床症状,提升疾病治疗效果,安全性高。

Clinical observation of octreotide combined with omeprazole in the treatment of mild upper gastrointestinal hemorrhage

Objective To evaluate the feasibility of octreotide combined with omeprazole in the treatment of mild upper gastrointestinal hemorrhage,so as to provide reference for the treatment of gastroenterological diseases.Methods A total of 80 patients with mild upper gastrointestinal hemorrhage were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with omeprazole,and the observation group was treated with omeprazole and octreotide.Both groups were compared in terms of clinical efficacy,occurrence of adverse reactions(nausea,abdominal distension,headache,etc.),negativeconversion time of fecal occult blood,hemostasis time,hospitalization time,platelet count,and activated partial thromboplastin time(APTT).Results The total effective rate of treatment 97.50% of the observation group was higher than 80.00% of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between 7.50% in the observation group and 5.00% in the control group(P>0.05).The negative-conversion time of fecal occult blood(2.10±0.50)d,hemostasis time(18.50±3.50)h,hospitalization time(5.20±1.30)d,and APTT(27.12±4.20)s in the observation group were shorter than(5.20±0.50)D,(37.50±4.50)h,(8.30±1.50)d,(33.50±4.50)s in the control group,and the platelet count(155.50±10.50)×10⁹/L was higher than(132.20±9.30)×10⁹/L in the control group.All the differences were statistically significant(P<0.05).Conclusion The application of octreotide and omeprazole treatment in patients with mild upper gastrointestinal hemorrhage can help improve the clinical symptoms of the patients,improve the therapeutic effect of the disease,and has high safety.