艾迪联合GP方案与GP方案治疗晚期非小细胞肺癌的效果研究

目的 观察艾迪联合GP方案(中药艾迪注射液、吉西他滨、顺铂联合的化疗方案)与GP方案(吉西他滨、顺铂化疗方案)对晚期非小细胞肺癌(NSCLC)患者疗效、毒性及生活质量的影响.方法 68例NSCLC患者,根据入院先后顺序分为A组(33例)及B组(35例).A组采用艾迪联合GP方案治疗,B组接受GP方案治疗.比较两组客观疗...

Efficacy of Aidi combined with GP regimen and sole GP regimen in the treatment of advanced non-small cell lung cancer

Objective To investigate the efficacy,toxicity of Aidi combined with GP regimen(a combined chemotherapy of traditional Chinese medicine Aidi injection,gemcitabine and cisplatin)and GP regimen(gemcitabine and cisplatin chemotherapy)and their effects on life quality of patients with advanced non-small cell lung cancer(NSCLC).Methods 68 patients with NSCLC were divided into Group A(33 cases)and Group B(35 cases)according to the order of their admissions.Patients in Group A were treated with Aidi combined with GP regimen,and patients in Group B were treated with GP regimen.The objective efficacy,median survival time(MST),clinical benefit rate and occurrence of toxic reaction were compared between the two groups.Results The difference in the overall response rate(ORR)between the two groups was not statistically significant(P>0.05).The disease control rate(DCR)of Group A was 57.6%,which was higher than 31.4%of Group B;the median survival time of Group A was 32 months,which was longer than 27 months of Group B;and the differences were statistically significant(P<0.05).Group A had positive rate of Karnofsky performance status(KPS)score of 51.5%and the positive rate of weight change of 45.5%,which were higher than 25.7%and 22.9%of Group B,respectively;the negative rate of KPS score of Group A was 21.2%,which was lower than 45.7%of Group B;and the differences were statistically significant(P<0.05).The proportion of patients had decreased white blood cell(WBC),vomiting and abnormal body temperature toxicity in Group A was lower than that in Group B,and the difference was statistically significant(P<0.05).The differences in decrease of platelet(PLT),reduction of hemoglobin(Hb),diarrhea,skin mucosa,ALT,blood urea nitrogen(BUN),electrocardiogram(ECG),toxicity grade III-IV of hair shedding between the two groups were not statistically significant(P>0.05).Neither side effects(such as drug-induced venous thrombosis),nor fatal toxic reactions were found in both groups.Conclusion There is no significant difference in the objective overall response rate between Aidi combined GP regimen and sole GP regimen in the treatment of NSCLC,but the combined chemotherapy of traditional Chinese medicine Aidi injection,gemcitabine and cisplatin had less toxic and side effects,long median life and obvious improvement of life quality of patients.