FDG-PET in the pretherapeutic evaluation of primary squamous cell carcinoma of the oral cavity and the involvement of cervical lymph nodes. |
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| Authors: | Matthias Hlawitschka Elisabeth Neise Jan Bredow Bettina Beuthien-Baumann Gunter Haroske Uwe Eckelt Wolf-Gunter Franke |
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| Affiliation: | 1. Technische Universität Dresden, Universitätsklinikum, Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Dresden, Germany;2. Klinik und Poliklinik für Nuklearmedizin, Dresden, Germany;3. Institut für Pathologie, Dresden, Germany;1. Karolinska Institutet, Stockholm, Sweden;2. Stockholm Spine Center, Stockholm, Sweden;3. King''s College, London, United Kingdom;4. Cardiff University School of Medicine, Cardiff, United Kingdom;5. University of North Carolina, Chapel Hill, North Carolina;6. University Hospital, Cologne, Germany;7. University of Göttingen, Göttingen, Germany;1. Division of Cancer & Genetics, Cardiff University, Cardiff, UK;2. Department of Pathology, University Hospital of Wales, Cardiff, UK;3. Wales Research & Diagnostic PET Imaging Centre, Cardiff, UK;4. Department of Upper GI Surgery, University Hospital of Wales, Cardiff, UK;5. Department of Clinical Radiology, University Hospital of Wales, Cardiff, UK;1. PET Center, Huashan Hospital, Fudan University, No. 518, East Wuzhong Road, Xuhui District, Shanghai 200235, China;2. Department of Radiology, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Jing’an District, Shanghai 200040, China;1. Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland;2. Department of Medical Oncology and Harry J. Duffey Family Program in Palliative Care, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland;1. Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases (OMCC), Japan;2. Department of Surgery, Saiseikai Senri Hospital, Japan;1. Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut;2. Yale Cancer Center, New Haven, Connecticut |
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| Abstract: | PURPOSE: The diagnostic role of positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) in squamous cell carcinoma of the oral cavity is evaluated. PROCEDURES: In 38 patients, the results of FDG-PET, magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound were compared. The standard uptake values (SUV) of FDG-PET were correlated to histopathological grading and DNA-image cytometry. RESULTS: In the case of lymph node metastases, the sensitivity of FDG-PET (93%) was higher than the sensitivity for the compared methods. The specificity was best for CT. SUVs of diploid tumor cell lines seemed to be lower than in non-diploid tumor cell lines. CONCLUSIONS: The high sensitivity and the high negative predictive value of PET may lead to more restrictive therapeutic regimens regarding lymph node metastases. Studies are necessary regarding possible relationships between glucose metabolism and tumor grading. |
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