120例非小细胞肺癌患者糖代谢水平及中医证型分析

目的:分析120例非小细胞肺癌患者的糖代谢水平和中医证型情况,探讨二者与肺癌复发转移的相关性。方法:运用回顾性研究方法,对120例非小细胞肺癌复查患者的基线资料、血糖水平、中医证型、复发转移情况进行统计分析并探讨其相关性。结果:纳入患者中,复发转移者的血糖水平明显高于未复发转移者(P0.05);各中医证型患者糖代谢水平不一,其中痰瘀毒结型最高,气滞血瘀型次之;各证型中,复发转移者血糖水平高于未复发者,但经t检验,仅痰瘀毒结型二者的差异有统计学意义(P=0.043),其他证型二者的差异无统计学意义(P 0.05)。结论:非小细胞肺癌复发转移患者糖代谢水平偏高,以实证多见,适时采用攻毒化痰散结等方法干预患者糖代谢是防治非小细胞肺癌复发转移的途径之一。

Analysis on Glucose Metabolism Level and Traditional Chinese Medicine Syndrome Types of 120 Patients with Non-Small Cell Lung Cancer

Objective:To analyze the glucose metabolism level and traditional Chinese medicine(TCM) syndrome types of 120 patients with non-small cell lung cancer(NSCLC),and to explore the relationship between them and how they relate to recurrence and metastasis of lung cancer. Methods:The retrospective method was used in the study. Firstly,the baseline data,glucose level,TCM syndrome types,recurrence and metastasis of 120 patients with NSCLS were collected. Secondly,the collected data were analyzed statistically.Thirdly,the relationship among the data was discussed. Results:In the included patients,the blood sugar level of patients with recurrence and metastasis was significantly higher than that of the patients without re currence and metastasis(P<0.05). The glucose metabolism level varied among different TCM syndrome types:Patients of phlegm-blood stasis and toxin accumulation type had the highest glucose metabolism level,followed by the qi stagnation and blood stasis type. The blood sugar level of patients with recurrence and metastasis was higher than that of patients without recurrence and metastasis. However,according to the t test,the difference of glucose metabolism level between patients with and without recurrence and metastasis was statistically significant only in the phlegm-blood stasis and toxin accumulation type(P= 0.043). In the other types,the differences were not statistically significant(P> 0.05). Conclusion:The glucose metabolism level of patients with recurrence and metastasis of NSCLS was higher and excessive syndrome was the common syndrome type in those patients. Therefore,using methods of combating poison,resolving phlegm and dispersing knots to intervene the glucose metabolism is one of the approaches to prevent the recurrence and metastasis of NSCLC.