Grafting antibiofilm polymer hydrogel film onto catheter by SARA SI-ATRP |
| |
| Authors: | Chao Zhou Hongqin Song Jia Ling Celestine Loh Jueqin She Linhong Deng |
| |
| Affiliation: | 1. Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu, China;2. zhouchao@cczu.edu.cn;4. College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China;5. School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore;6. College of Materials Science and Engineering, Changsha University of Science and Technology, Changsha, Hunan, China |
| |
| Abstract: | AbstractCatheters are widely used and play an important role in medicine. However, catheter-associated infection is prevalent even under stringent sterile conditions. Biofilms are formed when bacteria populate the surfaces of catheters. This makes the biofilm resistant to antibiotics. Hence, it is imperative for there to be an inherently antifouling and anti-bacterial catheter to mitigate the formation of biofilm. This paper aims to outline the synthesis of non-leachable anti-biofilm and anti-bacterial cationic film coatings through direct polymerization using supplemental activator and reducing agent surface initiated atom transfer radical polymerization (SARA SI-ATRP). Three crosslinked cationic coatings comprising of Diallyl dimethyl ammonium chloride (DADMAC), or ε-poly-L-lysine HCl methacrylic acid (EPL-MA) together with a crosslinker (polyethylene glycol dimethacrylate, PEGDMA) were investigated. These non-leachable covalently linked coatings with DADMAC can achieve more than 2 log reduction (99.0%) with Methicillin-resistant Staphylococcus aureus (MRSA) and 1.25 log reduction (94.4%) with Vancomycin resistant Enterococcus (VRE) in in vitro studies. |
| |
| Keywords: | Surface modification antibiofilm coating SARA SI-ATRP antibacterial property cationic polymer log reduction |
|
|
