脑梗死患者尿液11脱氢血栓烷B2与风险因素交互作用对疾病发生的影响

目的 分析脑梗死患者尿液11脱氢血栓烷B2（11 dehydrothromboxane B2，11-DH-TXB2）浓度与吸烟史、饮酒史、高血压病史及糖尿病史的交互作用，明确11-DH-TXB2在脑梗死疾病发生及预防中的价值。方法 选取脑梗死患者117例，健康对照组50例。收集患者一般资料、吸烟史、饮酒史、高血压及糖尿病病史，检测11-DH-TXB2浓度。分析11-DH-TXB2在两组间的差异并进行11-DH-TXB2与其他脑血管病风险因素交互作用相加模型分析。结果 两组患者一般资料差异无统计学意义（P>0.05）。尿液11-DH-TXB2浓度、吸烟史、糖尿病史、高血压史两组间差异有统计学意义（P<0.05），饮酒史在两组间差异无统计学意义（P>0.05）。交互作用相加模型分析以干扰因素阴性（－/－）为对照度，设OR值为1，11-DH-TXB2升高与吸烟史的交互作用指数（interaction index，S）为1.219，与高血压病史的S为5.578，与糖尿病史的S为4.604。结论 尿液11-DH-TXB2浓度与脑梗死发生存在相关性，并且与脑梗死患者的吸烟史、高血压病史、糖尿病病史之间存在协同交互作用。11-DH-TXB2可作为脑梗死预防的危险因素。

Influence of interaction between urine 11dehydrothromboxane B2 and other risk factors on disease occurrence in patients with cerebral infarction

Objective To analyze the interaction between urine 11 dehydrothromboxane B2(11-DH-TXB2) content and smoking history, drinking history, hypertension history and diabetes history in patients with cerebral infarction, and to clarify the value of 11-DH-TXB2 in the occurrence and prevention of cerebral infarction. Methods Totally 117 patients with cerebral infarction and 50 healthy controls were selected. The general data, smoking history, drinking history, hypertension and diabetes history of the patients were collected, and the content of 11-DH-TXB2 was detected. Statistical analysis was made on the difference between the two groups of 11-DH-TXB2, and the interaction model analysis between 11-DH-TXB2 and other cerebrovascular disease risk factors was carried out. Results There was no statistical difference in general data between the two groups (P>0.05). The urine 11-DH-TXB2 content, smoking history, diabetes history and hypertension history showed statistical significance between the two groups (P<0.05), while drinking history showed no statistical significance between the two groups (P>0.05).In the analysis of interaction additive model, negative interference factor (-/-) was taken as the contrast illuminance, and the OR value was set to 1, the interaction effect index (S) of the increase of 11-DH-TXB2 and smoking history was set to 1.219, the increase of 11-DH-TXB2 and hypertension history S were set to 5.578, the increase of 11-DH-TXB2 and diabetes history S were set to 4.604. Conclusion Urine 11-DH-TXB2 content is correlated with the occurrence of cerebral infarction, and has synergistic interaction with smoking history, hypertension history and diabetes history of cerebral infarction patients. 11-DH-TXB2 can be used as a risk factor for cerebral infarction prevention.