HEPATOPROTECTIVE EFFECT OF AMOORA ROHITUKA |
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Authors: | M. K. Gole S. Dasgupta R. K. Sur J. Ghosal |
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Affiliation: | 1. Department of Physiology, University College of Science and Technology, 92, A.P.C. Road, Calcutta, 700 009, India;2. Animal Physiology and Biochemistry Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Calcutta, 700 019, India;3. Physiology Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta, 700 032, India |
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Abstract: | AbstractAntihepatotoxic activity of a resuspended residue of the alcohol extract of Amoora rohituka W & A. (Meliaceae) was studied in rats with hepatic injury induced by carbon tetrachloride. Carbon tetrachloride (1 ml/kg, i.p.) was administered twice a week for 3 weeks and an extract of A. rohituka (50 mg/kg/day) was given orally for the same period. The rats were sacrificed 24 h after the last CC14 challenge. Carbon tetrachloride induced elevations of alkaline phosphatase (ALP), glutamate pyruvate transaminase (CPT), alanine aminotransferase (ALAT), glutamate oxaloacetate transaminase (GOT), aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH) and total plasma bilirubin concentration as well as depression of total plasma cholesterol concentration were reduced significantly by the concurrent treatment of rats with A. rohituka suspension. Changes in the histological architecture of the liver produced by CC14 where also protected by the administration of A. rohituka suspension. These results indicate that A. rohituka suspension possesses hepatoprotective action. |
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Keywords: | Amoora rohituka W. & A. antihepatotoxic activity carbon tetrachloride cirrhosis necrosis |
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