Effect of bisphosphonates on the increase in bone resorption induced by a low calcium diet |
| |
Authors: | V N Antic H Fleisch R C Mühlbauer |
| |
Institution: | (1) Department of Pathophysiology, University of Berne, Berne, Switzerland;(2) Laboratory for Clinical and Experimental Research, University of Berne, Tiefenaustrasse 120, 3004 Berne, Switzerland |
| |
Abstract: | This study investigates whether bisphosphonate-treated rats are still able to adapt to low calcium supply through an increase
in bone resorption assessed by measuring the urinary excretion of 3H]-tetracycline from chronically prelabeled rats. First it was shown that in this model, parathyroid hormone was responsible
for the increase in bone resorption on the low calcium diet. In the second part, animals were treated with the three bisphosphonates—clodronate,
alendronate, and ibandronate—given in two doses. Animals receiving a dose that already strongly inhibits bone resorption were
still able to respond to a low calcium diet by increasing bone resorption, showing the potency of the latter as a stimulator
of bone resorption. Higher doses were, however, able to blunt this response. As soon as the treatment was discontinued, this
increase in bone resorption resumed with clodronate but not with alendronate or ibandronate. |
| |
Keywords: | Bisphosphonates Low calcium diet Bone resorption |
本文献已被 SpringerLink 等数据库收录! |
|