| 红景天甙对人肝癌细胞c-myc表达的逆转作用 |
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| 引用本文： | 解方为,欧阳学农,蒋明德. 红景天甙对人肝癌细胞c-myc表达的逆转作用[J]. 西南国防医药, 2006, 16(2): 130-131 |
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| 作者姓名： | 解方为 欧阳学农 蒋明德 |
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| 作者单位： | 1. 南京军区福州总医院肿瘤科,福建,福州,350025
2. 成都军区总医院消化内科,四川,成都,610083 |
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| 摘 要： | 目的:研究红景天甙对人肝癌细胞系SMMC-7721的c-myc表达的逆转作用。方法:通过不同剂量红景天甙处理体外培养的SMMC-7721细胞株,采用免疫组织化学检测细胞c-myc表达。结果:不同终浓度(0.5mg/ml、1.0mg/ml、1.5mg/ml)的红景天甙均能抑制SMMC-7721细胞C-myc表达,抑制率分别为8.8%、21.6%和39.8%(P<0.01)。其抑制作用呈剂量效应正相关。结论:红景天甙可抑制SMMC-7721细胞内c-myc的表达,提示其在体外诱导肝癌细胞分化的可能。
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| 关 键 词： | 人肝癌细胞 诱导分化 红景天甙 |
| 文章编号： | 1004-0188（2006）02-0130-02 |
| 收稿时间： | 2005-11-21 |
| 修稿时间： | 2005-11-21 |
Reverse effects of salidroside on expression of c-myc in SMMC-7721 cell line in vitro |
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| XIE Fang-wei,OUYANG Xue-nong,JIANG Ming-de. Reverse effects of salidroside on expression of c-myc in SMMC-7721 cell line in vitro[J]. Medical Journal of National Defending forces in Southwest China, 2006, 16(2): 130-131 |
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| Authors: | XIE Fang-wei OUYANG Xue-nong JIANG Ming-de |
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| Affiliation: | 1. Department of Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, 350025; 2. Department of Enterology, General Hospital of Chengdu Military Command, Chengdu, 610083 |
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| Abstract: | Objective:To study the reverse effects of salidroside on expression of c-myc in SMMC-7721 cell line.Methods: The cultured SMMC-7721 cell lines were pre-treated by different dosages of salidroside in vitro and then the level of expression of c-myc was determined with immunohistochemistry.Results: All of three dosage(0.5 mg/ml,1.0 mg/ml and 1.5 mg/ml) of salidroside could inhibited the expression of c-myc in SMMC-7721 cell lines and inhibited rates were 8.8%,21.6% and 39.8%,respectively.There was a positive dosage-dependent relationship.Conclusion: Salidroside is of reverse effects on expression of c-cym in SMMC-7721 cell lines,which indicates that it may induce differentiation of hepatoma carcinoma cell in vitro. |
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| Keywords: | hepatoma carcinoma cell salidroside induction of differentiation c-cym |
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