山莨菪碱联用地塞米松对四氧化二氮爆炸致冲毒复合伤大鼠血气的影响

目的 通过复制N2O4爆炸致冲毒复合伤模型，研究山莨菪碱联用地塞米松对实验动物血气的影响。方法 采用健康雄性Wistar大鼠224只，随机分用：①模型组：冲击伤加N2O4染毒复合致伤；②山莨菪碱组：伤后即刻、伤后15min、伤后2h分别腹腔注射山莨碱3mg/kg，共3次；③地塞米松组：伤后即刻、15min、2h分别腹腔注射地塞米松10mg/kg，共3次。④山莨菪碱和地塞米松组：伤后3次注射山莨菪碱3mg/kg及地塞米松10mg/kg。结果 模型组血氧分压明显下降，二氧化碳分压上升，血红蛋白氧合能力下降，组织氧供下降，血液酸化明显。早期腹腔注射山莨菪碱或地塞米松对四氧化二氮冲毒复合伤动物血气变化有一定的抑制作用。而两者联合应用对血气变化有显著的逆转作用。结论 联合应用山莨菪碱和地塞米松对四氧化二氮冲毒复合伤的治疗有效。

The effect of the anisodaminum and dexamethasone on the changes of blood gas of the rats following the blast-toxicosis combined injury by the explosion of the nitrogen tetroxide

Objectve　To investigate the effects of anisodaminum and dexamethasone on the changes of blood gas of the N2O4 blast-toxicosis combined injury model.　Methods　Two hundred and twenty-four male Wistar rats were divided randomly into 4 groups: ①N2O4 blast-toxicosis combined injury model group; ②Anisodaminum treated group； anisodaminum (3 mg/kg) was given ip right after, 15 min after and 2 h after the injury; ③Dexamethasone treated group； dexamethasone (10 mg/kg) was given ip right after the injury, 15 min after and 2 h after the injury; ④Anisodaminum and dexamethasone combine-treated group； anisodaminum (3 mg/kg) and dexamethasone (10 mg/kg) were given ip right after, 15 min after and 2 h after the injury. Each group was subdivided into control group and 6 treatment groups which were killed 3, 6, 12, 24, 48, 72 hours after the injury for blood gas analysis. 　Results　In N2O4 blast-toxicosis model group PaO2 and pH of the plasma were significantly decreased, while PaCO2 was increased . Combined use of anisodaminum and dexamethasone in the early stage significantly ameliorated the disorders of the blood gas of the combined injury.　Conclusion　It is suggested that the combined use of anisodaminum and dexamethasone in the early stage is effective in the treatment of blast-toxicosis combined injury caused by the explosion of the nitrogen tetroxide.