Antiemesis After Total Joint Arthroplasty: Does a Single Preoperative Dose of Aprepitant Reduce Nausea and Vomiting? |
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| Authors: | Timothy M DiIorio Peter F Sharkey Agnes M Hewitt Javad Parvizi |
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| Institution: | (1) Temple University School of Medicine, Philadelphia, PA, USA;(2) Department of Orthopaedic Surgery, Rothman Institute at Thomas Jefferson University, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA;(3) Thomas Jefferson University Hospital, Philadelphia, PA, USA;(4) Family Medicine, Riddle Memorial Hospital, Media, PA, USA |
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| Abstract: | Background Postoperative nausea and vomiting (PONV) is frequent after joint arthroplasty; in addition to causing patient distress, it
interferes with early mobilization and hospital discharge. Various antiemetic agents reduce PONV, but their action is limited
by a short half-life. Aprepitant, an antiemetic developed for patients receiving chemotherapy, has a duration of action much
longer than other antiemetics. |
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