DOUBLE-BLIND STUDY OF THE REVERSAL OF MIDAZOLAM-SUPPLEMENTED GENERAL ANAESTHESIA WITH RO 15-1788 |
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Authors: | ALON E; BAITELLA L; HOSSLI G |
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Institution: | Institute of Anaesthesiology, University Hospital of Zurich 8091 Zurich, Switzerland |
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Abstract: | The actions and side effects of the benzodiaze-pine antagonistRo 151788 were evaluated in a randomized double-blindclinical study in which midazolam was used as an anaestheticagent. Sixty women who underwent laparoscopy were treated withRo 151788 or with placebo after the surgical procedure.Ro 151788 reversed the hypnotic effect of midazolam withina few minutes. The patients were alert, co-operative, orientedand had good recall of events after awakening. The effects werestatistically better than placebo for up to 30 min after administration.Arterial pressure and heart rate remained stable and there wereno significant side effects. The availability of Ro 151788allows effective reversal of midazolam when this is used duringgeneral anaesthesia.
Presented at the 18th Congress of the Scandinavian Society ofAnaesthesiologists, Reykjavik, Iceland, June 2529, 1985and at the 19th Central European Congress of Anaesthesiology,Graz, Austria, September 1014, 1985. |
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