| 二甲苯对大鼠记忆功能和c—fos基因表达的影响 |
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| 引用本文： | 王秀玲,笪翠娣.二甲苯对大鼠记忆功能和c—fos基因表达的影响[J].中华劳动卫生职业病杂志,1999,17(2):88-90. |
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| 作者姓名： | 王秀玲 笪翠娣 |
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| 作者单位： | 上海医科大学劳动卫生学教研室，中国预防医学科学院劳动卫生与职业病研究所，神经生物国家重点实验室 |
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| 摘 要： | 目的探讨二甲苯对大鼠学习记忆功能的影响及其机制。方法采用反映学习记忆功能的水迷宫法和步下法测试大鼠神经行为的改变；免疫组化法研究大鼠脑组织ＦＯＳ免疫反应（ＦＯＳＩＲ）阳性胞核的水平。结果二甲苯使大鼠学习记忆能力下降，大脑皮层及海马区内均有较多的ＦＯＳ蛋白阳性细胞。结论二甲苯可损伤大鼠学习记忆能力，且这种改变可能与脑组织内ｃｆｏｓ的表达有关系
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| 关 键 词： | 二甲苯 神经行为 学习记忆 c-foS |
Effects of xylene on learning memory ability and c fos gene expression in rats |
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| Wang Xiuling ,Da Cuidi,Wang Xuping,et al..Effects of xylene on learning memory ability and c fos gene expression in rats[J].Chinese Journal of Industrial Hygiene and Occupational Diseases,1999,17(2):88-90. |
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| Authors: | Wang Xiuling Da Cuidi Wang Xuping |
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| Institution: | Wang Xiuling *,Da Cuidi,Wang Xuping,et al. *Department of Occupational Health,Shanghai Medical University,Shanghai 200032 |
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| Abstract: | Objective To study the effects of xylene on learning and memory ability in rats and its relation with c fos gene expression. Methods Spatial water maze and step down tests were applied to study the effects of xylene on learning and memory ability in rats.Expression of FOS protein in cortical and hippocampus was observed by immunohistochemical method. Results The learning and memory ability was declined and FOS like immunoreactive(FOS IR) nuclei was induced both in cortical and hippocampus in high dose group(500 mg/kg). Conclusion Xylene may damage the learning memory ability of the rats in high dose and there may be a relationship between the declined ability of learning memory ability and c fos gene expression. |
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| Keywords: | Xylene Neurobehavior Learning memory c fos |
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