| Alzheimer病1H磁共振波谱成像 |
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| 引用本文： | 钱丽霞,祁吉,尹建忠,李鹏.Alzheimer病1H磁共振波谱成像[J].中国CT和MRI杂志,2005,3(3):14-18. |
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| 作者姓名： | 钱丽霞 祁吉 尹建忠 李鹏 |
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| 作者单位： | 1. 山西医科大学第一附属医院放射科
2. 天津医科大学第一中心医院放射科;天津市影像医学研究所 |
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| 摘 要： | 目的研究Alzheimer病(AD)、轻度认知障碍(MCI)患者的氢质子磁共振波谱的改变,并与认知正常的老年志愿者(NC)进行比较.方法对AD组15例、MCI组20例及NC组20例患者行磁共振波谱成像,测定双侧海马、双侧颞顶叶联合区的NAA/Cr,Cho/Cr,mI/Cr.结果AD、MCI及NC 3组间海马的NAA/Cr有显著性差异(P＜0.05),AD-NC、AD-MCI组间颞顶联合区NAA/Cr有显著性差异(P＜0.05).结论磁共振波谱分析可发现AD、MCI患者海马及颞顶联合区的NAA/Cr,mI/Cr改变.
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| 关 键 词： | 氢质子磁共振波谱 Alzheime病 认知障碍 AD 影像学 |
| 修稿时间： | 2005年5月9日 |
Imaging of Alzheimer's disease with 1H MRS |
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| Authors: | QIAN Li-xia QI Ji YIN Jian-zhong |
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| Institution: | QIAN Li-xia,QI Ji,YIN Jian-zhong,et al. Department of Radiology,the First AffiliatedHospital of Shanxi Medical University,Taiyuan 030021,China[ |
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| Abstract: | Objective To investigate changes of proton magnetic resonance spectroscopy(1H MRS) in Alzheimer disease(AD) and mild cognitive impairment(MCI) in comparisonwith senior volunteers who have normal cognitive(NC). Methods MRS were administeredto 15 patients with AD, 20 patients with MCI, and 20 volunteers, determining NAA/Cr,Cho/Cr, and mI/Cr in bilateral hippocampi and temporoparietal regions. ResultsNAA/Cr and mI/Cr of bilateral hippocampi region in AD, MCI and NC weresignificantly different(P < 0.05); NAA/Cr of bilateral temporoparietal region weresignificantly different in AD-NC and AD-MCI pair comparisons (P < 0.05). ConclusionMRS can be used to detect changes of NAA/Cr and mI/Cr in hippocampi andtemporoparietal regions. |
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| Keywords: | proton magnetic resonance spectroscopy Alzheimer disease mild cognitive impairment |
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