| 99Tcm-HMPAO在大鼠大脑神经细胞内的分布研究 |
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| 引用本文： | 李志杰,谭斐,裴著果,张彩霞. 99Tcm-HMPAO在大鼠大脑神经细胞内的分布研究[J]. 中华核医学杂志, 2001, 21(6): 353-354,I002 |
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| 作者姓名： | 李志杰 谭斐 裴著果 张彩霞 |
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| 作者单位： | 1. 中国医科大学第二临床学院核医学科，沈阳，110003
2. 中国医科大学第二临床学院神经内科，沈阳，110003 |
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| 基金项目： | 辽宁省社会发展基金资助项目 (992 2 50 0 1 ) |
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| 摘 要： | 目的：探讨^99Tc^m-6甲基丙二胺肟（HMPAO）在神经细胞内的分布特点。方法：采用脑血流放射自显影方法观察3只正常大鼠和11只大脑中动脉栓塞（MCAO）大鼠光镜与电镜下神经细胞内^99Tc^m-－HMPAO银颗粒的分布特点。结果：^99Tc^m-HMAPO主要分布在神经细胞的胞浆及突起中，不同细胞对^99Tc^m-－HMPAO的摄取不尽相同。MCAO后缺血半暗区^99Tc^m-HMPAO弥漫性分布稀疏，梗死区几乎无摄取。结论：^99Tc^m-HMPAO在神经细胞内的滞留可能与浆液内进行的代谢过程有关。
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| 关 键 词： | 脑栓塞 HMPAO 放射自显影 神经细胞 |
A study on the location of 99 Tcm-HMPAO in neurons of rat brain |
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| LI Zhijie,TAN Fei,PEI Zhuguo,et al.. A study on the location of 99 Tcm-HMPAO in neurons of rat brain[J]. Chinese Journal of Nuclear Medicine, 2001, 21(6): 353-354,I002 |
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| Authors: | LI Zhijie TAN Fei PEI Zhuguo et al. |
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| Affiliation: | LI Zhijie*,TAN Fei,PEI Zhuguo,et al. *Department of Nuclear Medicine,The Second Clinical Hospital,China Medical University,Shenyang 110003,China |
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| Abstract: | Objective To study the location of 99Tcm-HMPAO in neurons. Methods Cerebral blood flow autoradiography was done in 3 normal rats and 11 rats with right middle cerebral artery occlusion(MCAO) and observed with light and electron microscope. Results 99Tcm-HMPAO silver particles were observed in the cytoplasm and processes of normal neurons and the distribution was not even among different neurons. In MCAO rats, the distribution of 99Tcm-HMPAO silver particles showed diffuse decrease in ischemic penumbra and almost disappeared in the infarcted core. Conclusion The retention of 99Tcm-HMPAO in neurons might be correlated with the metabolic process taking place in cytoplasm. |
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| Keywords: | Brain Cells HMPAO Rats Autoradiography |
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