Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome |
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| Authors: | Alhopuro P Katajisto P Lehtonen R Ylisaukko-Oja S K Näätsaari L Karhu A Westerman A M Wilson J H P de Rooij F W M Vogel T Moeslein G Tomlinson I P Aaltonen L A Mäkelä T P Launonen V |
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| Affiliation: | Department of Medical Genetics, Biomedicum Helsinki (Haartmaninkatu 8), University of Helsinki, Helsinki FIN-00014, Finland. |
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| Abstract: | Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in 28 LKB1-negative PJS patients. No disease-causing mutations were detected in the studied genes in PJS patients from different European populations. |
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| Keywords: | Peutz–Jeghers syndrome BRG1 STRADα MO25α LKB1 |
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