连续性肾脏替代疗法治疗急性肾功能衰竭的临床观察

目的观察连续性肾脏替代疗法（CRRT）治疗重症急性肾功能衰竭（ARF）的疗效和对预后的影响。方法对2003年以来16例ARF（伴发多器官功能障碍综合征,MODS）患者进行CRRT的临床资料回顾性分析。结果11例患者经CRRT治疗24 h后,生命指征平稳,BUN、Scr下降（P〈0.05）,二氧化碳结合力（CO2CP）正常,85-264h后进入多尿期;5例患者死于严重创伤或MODS。治疗过程中无低体温和低血压等并发症。结论CRRT治疗重症ARF患者,血液动力学稳定,溶质清除率高,有利于营养支持及清除炎性细胞因子,从而改善重症ARF患者的预后。

Continuous renal replacement therapy for acute renal failure

Objective To evaluate the efficacy and prognostic significance of continuous renal replacement therapy on acute renal failure.Methods Clinical characteristics of 16 patients with acute renal failure(accompanied with multiple organ dysfunction syndromes) were retrospectively studied.Results Vital signs of 11 patients become normal after 24 hours of Continuous renal replacement therapy,BUN and Scr decreased(P<0.05),CO2CP became normal,the patients were present with polyuria,5 patients died of severe trauma and MODS.Conclusion Continuous renal replacement therapy is effective in maintaining stable hemodynamics,removing inflammatory mediators and improving the prognosis.