The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients |
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| Authors: | Chew Sin-Chi Singh Onkar Chen Xiangai Ramasamy Rathi Devi Kulkarni Tejal Lee Edmund J D Tan Eng-Huat Lim Wan-Teck Chowbay Balram |
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| Affiliation: | (1) Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore, 117597, Singapore;(2) Division of Medical Sciences, Laboratory of Clinical Pharmacology, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore;(3) Department of Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore; |
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| Abstract: | Purpose This exploratory study aimed to explain the interindividual variabilities of docetaxel pharmacokinetics and pharmacodynamics in Asian nasopharyngeal carcinoma patients (n = 54) through the genotyping of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 genes. |
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