Antihyperglycaemic and aldose reductase inhibitory potential of Acacia catechu hard wood and Tectona grandis leaves |
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| Authors: | Vikram Bhatia Swayam P Srivastava Rohit Srivastava Akansha Mishra T Narender Rakesh Maurya Arvind K Srivastava |
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| Institution: | (1) Division of Biochemistry, Central Drug Research Institute, Lucknow, 226001, India;(2) Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, 226001, India; |
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| Abstract: | The ethanolic extract of Acacia catechu hard wood (Ac) and the ethanolic as well as aqueous extracts of Tectona grandis leaves (Tg) showed marked antihyperglycaemic activity in both normoglycaemic and streptozotocin-induced diabetic rats at
250 mg/kg dose levels. The ethanolic and aqueous extracts of Ac and Tg also showed marked inhibition on AR from eye lens of
normal rats with IC 50 values of 9.30 and 9.08 and 3.05, 4.51 μg/ml, respectively. The ethanolic as well as aqueous extracts
of both Ac and Tg also showed marked inhibition on AR from eye lens of STZ-induced diabetic rats with IC50 values of 4.70 and 4.91 and 4.71 and 4.83 μg/ml. These results suggest that Acacia catechu hard wood and Tectona grandis leaves could be a new approach in the development of therapeutic or preventive agents for diabetic late-stage complications. |
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