血管性认知障碍载脂蛋白E基因多态性与中医辨证的相关性研究

目的探讨血管性认知障碍（VCI）载脂蛋白E基因（ApoE）多态性与中医辨证的相关性。方法研究共纳入105例健康对照组（NC组）及103例血管性认知障碍患者（VCI组）,将VCI组进一步诊断为血管性痴呆（VaD）亚组35例和非痴呆型血管性认知障碍（VCIND）亚组68例,检测其ApoE基因型与中医辨证分型相关性。结果 VCI组中VaD亚组E3/3基因型、ε3等位基因频率明显低于NC组;E3/4基因型及ε4等位基因频率明显高于NC组;VCI患者中E3/4基因型及ε4等位基因在肾精亏虚证、痰浊阻窍证、瘀血阻窍证阳性率较高,均有统计学意义（P〈0.05）。结论 ApoEε4基因可能是VCI患者中VaD亚型的危险因素,与VCI患者发生肾精亏虚证、痰浊阻窍证、瘀血阻窍证有关。

Relativity between vascular cognitive impairment apolipoprotein E gene polymorphism and TCM syndrome

Objective To probe into the relativity between vascular cognitive impairment apolipoprotein E gene polymorphism and TCM syndrome. Methods 103 vascular cognitive impairment patients were recruited as VCI group in this study, They were subdivided into 35 patients of VaD subgroup and 68 patients of VCIND subgroup, and there were 105 healthy people recruited as normal control（NC） group,to detect the relativity between ApoE gene and TCM syndrome. Results Allele frequencies such as E3/3 genotype and ε3 in the VaD subgroup of the VCI group were significantly lower than those in the NC group;While, allele frequencies such as E3/4 genotype and ε4 in the VaD subgroup of the VCI group were significantly higher than those in the NC group;The positive frequencies of the allele such as E3/4 genotype and ε4 in the VCI patients were higher in the syndromes of kidney deficiency, turbid phlegm blocking upper orifices, blood stasis blocking upper orifices （P 〈 0.05）. Conclusion ApoE ε4 gene maybe the risk factor in VaD subtype patients, maybe associated with the syndromes of kidney deficiency, turbid phlegm blocking upper orifices, blood stasis blocking upper orifices of the VCI patients.